Seroatlas · Human Serome Atlas

SMIM10L1

Small integral membrane protein 10-like protein 1

Also known as: SIML1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DMW3
Gene
SMIM10L1
Ensembl
ENSG00000256537
Chromosome
12
Canonical length
68 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

68 residues, UniProt reviewed canonical sequence.

>P0DMW3|SMIM10L1
     1  MAPAAAPSSL AVRASSPAAT PTSYGVFCKG LSRTLLAFFE LAWQLRMNFP YFYVAGSVIL
    61  NIRLQVHI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMIM10L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 21 nTPM
  • spinal cord: 17 nTPM
  • midbrain: 16 nTPM
  • adrenal gland: 15 nTPM
  • heart muscle: 14 nTPM
  • hippocampal formation: 14 nTPM

Single-cell type

  • other brain neurons: 26 nCPM
  • oligodendrocytes: 21 nCPM
  • brain excitatory neurons: 19 nCPM
  • brain inhibitory neurons: 18 nCPM
  • oligodendrocyte progenitor cells: 13 nCPM
  • bergmann glia: 12 nCPM

Immune cell

  • basophil: 22 nTPM
  • NK-cell: 13 nTPM
  • eosinophil: 12 nTPM
  • T-reg: 10 nTPM
  • naive CD4 T-cell: 10 nTPM
  • classical monocyte: 9.7 nTPM

Brain region

  • spinal cord: 16 nTPM
  • midbrain: 15 nTPM
  • thalamus: 15 nTPM
  • hypothalamus: 15 nTPM
  • white matter: 14 nTPM
  • hippocampal formation: 14 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMIM10L1 as an antibody target. Whether an autoantibody or antibody against SMIM10L1 could matter depends on whether native SMIM10L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMIM10L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMIM10L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMIM10L1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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