Seroatlas · Human Serome Atlas

SMIM10

Small integral membrane protein 10

Also known as: CXorf69, SIM10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96HG1
Gene
SMIM10
Ensembl
ENSG00000184785
Chromosome
X
Canonical length
83 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

83 residues, UniProt reviewed canonical sequence.

>Q96HG1|SMIM10
     1  MEALGSGHYV GGSIRSMAAA ALSGLAVRLS RPQGTRGSYG AFCKTLTRTL LTFFDLAWRL
    61  RKNFFYFYIL ASVILNVHLQ VYI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMIM10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
49 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 49 nTPM
  • spinal cord: 30 nTPM
  • testis: 26 nTPM
  • parathyroid gland: 23 nTPM
  • urinary bladder: 17 nTPM
  • adipose tissue: 16 nTPM

Single-cell type

  • erythrocyte progenitors: 65 nCPM
  • vascular smooth muscle cells: 62 nCPM
  • sertoli cells: 59 nCPM
  • fallopian tube ciliated cells: 57 nCPM
  • megakaryocytes: 50 nCPM
  • megakaryocyte-erythroid progenitors: 40 nCPM

Immune cell

  • NK-cell: 3.4 nTPM
  • eosinophil: 2 nTPM
  • basophil: 1.5 nTPM
  • naive B-cell: 0.7 nTPM
  • classical monocyte: 0.3 nTPM
  • intermediate monocyte: 0.2 nTPM

Brain region

  • medulla oblongata: 15 nTPM
  • white matter: 15 nTPM
  • spinal cord: 15 nTPM
  • pons: 14 nTPM
  • midbrain: 13 nTPM
  • hypothalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.86
gnomAD pLI
0.32
gnomAD missense Z
0.81
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMIM10 as an antibody target. Whether an autoantibody or antibody against SMIM10 could matter depends on whether native SMIM10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMIM10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMIM10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMIM10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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