Seroatlas · Human Serome Atlas

SMDT1

Essential MCU regulator, mitochondrial

Also known as: C22orf32, DDDD, dJ186O1.1, EMRE, EMRE_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H4I9
Gene: SMDT1
Ensembl: ENSG00000183172
Chromosome: 22
Canonical length: 107 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

This gene encodes a core regulatory component of a calcium channel in the mitochondrial inner membrane. [provided by RefSeq, Apr 2017]

Canonical amino-acid sequenceUniProt

107 residues, UniProt reviewed canonical sequence.

>Q9H4I9|SMDT1
     1  MASGAARWLV LAPVRSGALR SGPSLRKDGD VSAAWSGSGR SLVPSRSVIV TRSGAILPKP
    61  VKMSFGLLRV FSIVIPFLYV GTLISKNFAA LLEEHDIFVP EDDDDDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMDT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 37 nTPM
tongue: 35 nTPM
amygdala: 27 nTPM
cerebral cortex: 25 nTPM
basal ganglia: 24 nTPM
cerebellum: 23 nTPM

Single-cell type

parietal cells: 504 nCPM
esophageal apical cells: 427 nCPM
gastric chief cells: 381 nCPM
late primary spermatocytes: 351 nCPM
enterocytes: 319 nCPM
epididymal efferent duct absorptive cells: 317 nCPM

Immune cell

naive CD4 T-cell: 9.5 nTPM
memory CD4 T-cell: 8.7 nTPM
myeloid DC: 8.5 nTPM
naive B-cell: 7.1 nTPM
plasmacytoid DC: 6.4 nTPM
naive CD8 T-cell: 6.1 nTPM

Brain region

cerebellum: 25 nTPM
white matter: 18 nTPM
cerebral cortex: 18 nTPM
basal ganglia: 18 nTPM
pons: 18 nTPM
hypothalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.61
gnomAD pLI: 0.18
gnomAD missense Z: -0.1
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Essential MCU regulator, mitochondrial
Putative mitochondrial precursor protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SMDT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMDT1 as an antibody target. Whether an autoantibody or antibody against SMDT1 could matter depends on whether native SMDT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMDT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMDT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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