Seroatlas · Human Serome Atlas

SMCR5

Smith-Magenis syndrome chromosomal region candidate gene 5 protein

Also known as: SMCR5_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TEV8
Gene: SMCR5
Canonical length: 140 aa

OverviewNCBI Gene

No narrative summary is available for SMCR5 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

140 residues, UniProt reviewed canonical sequence.

>Q8TEV8|SMCR5
     1  MRRCLRVKTR RGQLGLASSC FEQHSCFSPR VNRILSAVQN TLCTGPSSQA PPQPPQASPP
    61  AAADHSRTPS LLASSHSASG GESLFQLYIA SLAWPQNCCV LESCRRIPLG GLSSMENRRP
   121  LLRKGRLLRG QIHHSQTNEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMCR5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMCR5 as an antibody target. Whether an autoantibody or antibody against SMCR5 could matter depends on whether native SMCR5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMCR5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMCR5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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