Seroatlas · Human Serome Atlas

SMCO2

Single-pass membrane and coiled-coil domain-containing protein 2

Also known as: C12orf70, LOC341346, SMCO2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NFE2
Gene: SMCO2
Ensembl: ENSG00000165935
Chromosome: 12
Canonical length: 343 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

343 residues, UniProt reviewed canonical sequence.

>A6NFE2|SMCO2
     1  MALTPTNLNN KMSLQMKMDC QEQQLTKKNN GFFQKLNVTE GAMQDLLKEI IKVDHILDRS
    61  DDEDDISSEN PQTDFLHKGM LELEAEHDQD LSKQDKQETD VDEDPQASTS LQFSKKNLLE
   121  LCLKGMFLKL NYWNTKIGLQ VKELGADYID GTEKIDNIIK KINVTENTVK SLLKDMLTLK
   181  GQIEKLEDRG LDLDQGTSTE VNTCNEVYEL KKKVIERLED LCKNVELLSA KLRMYQMEAE
   241  DTDSHSSEEI DTEEMEALLP QAPASFLVQK SPPRNTAWKR ALRIFIMFDV LTVTGLLCYI
   301  LFFGATFLFE RVLLRMLGCR TTWDLREMRE PFLNLEVEAL LPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMCO2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 0.7 nTPM

Expression across tissuesHPA

Tissue

testis: 0.7 nTPM
choroid plexus: 0.5 nTPM
esophagus: 0.4 nTPM
skin: 0.4 nTPM
tonsil: 0.4 nTPM
appendix: 0.3 nTPM

Single-cell type

esophageal apical cells: 21 nCPM
hematopoietic stem cells: 19 nCPM
late primary spermatocytes: 15 nCPM
thymic myoid cells: 14 nCPM
early spermatids: 12 nCPM
retinal ganglion cells: 7.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 2.4 nTPM
midbrain: 1.9 nTPM
cerebral cortex: 1.7 nTPM
amygdala: 1.3 nTPM
white matter: 1.2 nTPM
basal ganglia: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.52
gnomAD pLI: 0
gnomAD missense Z: 0.8
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Transmembrane and coiled-coil domain-containing protein 2/5

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMCO2 as an antibody target. Whether an autoantibody or antibody against SMCO2 could matter depends on whether native SMCO2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMCO2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMCO2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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