Seroatlas · Human Serome Atlas

SMCO1

Single-pass membrane and coiled-coil domain-containing protein 1

Also known as: C3orf43, DKFZp313B0440, FLJ41923, SMCO1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q147U7
Gene: SMCO1
Ensembl: ENSG00000214097
Chromosome: 3
Canonical length: 214 aa
Protein class: Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum,Golgi apparatus

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

214 residues, UniProt reviewed canonical sequence.

>Q147U7|SMCO1
     1  MNNETTTLIS LKEAMKRVDH KLQALETQFK ELDFTKDNLM QKFEHHSKAL ASQAAQDEMW
    61  TAVRALQLTS MELNILYSYV IEVLICLHTR VLEKLPDLVR GLPTLASVLR RKVKNKRVRV
   121  VWESILEECG LQEGDITALC TFFIARGNKA EHYTAKVRQM YIRDVTFLIT NMVKNQALQD
   181  SLLRAVQVIE KGKAVRTPEK QKSSLEELIP SVKN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMCO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 140 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 140 nTPM
tongue: 100 nTPM
heart muscle: 39 nTPM
esophagus: 2.2 nTPM
prostate: 0.6 nTPM
salivary gland: 0.6 nTPM

Single-cell type

myonuclei: 47 nCPM
cardiomyocytes: 11 nCPM
early spermatids: 2.5 nCPM
late primary spermatocytes: 2.1 nCPM
early primary spermatocytes: 0.8 nCPM
rod photoreceptor cells: 0.8 nCPM

Immune cell

NK-cell: 0.3 nTPM
basophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 0.6 nTPM
cerebellum: 0.5 nTPM
hypothalamus: 0.5 nTPM
white matter: 0.5 nTPM
amygdala: 0.4 nTPM
basal ganglia: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.68
gnomAD pLI: 0
gnomAD missense Z: 0.58
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF4547
Domain of unknown function (DUF4547)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMCO1 as an antibody target. Whether an autoantibody or antibody against SMCO1 could matter depends on whether native SMCO1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMCO1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMCO1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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