Seroatlas · Human Serome Atlas

SMARCD3

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

Also known as: BAF60C, CRACD3, Rsc6p, SMRD3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6STE5
Gene
SMARCD3
Ensembl
ENSG00000082014
Chromosome
7
Canonical length
483 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

483 residues, UniProt reviewed canonical sequence.

>Q6STE5|SMARCD3
     1  MAADEVAGGA RKATKSKLFE FLVHGVRPGM PSGARMPHQG APMGPPGSPY MGSPAVRPGL
    61  APAGMEPARK RAAPPPGQSQ AQSQGQPVPT APARSRSAKR RKMADKILPQ RIRELVPESQ
   121  AYMDLLAFER KLDQTIMRKR VDIQEALKRP MKQKRKLRLY ISNTFNPAKP DAEDSDGSIA
   181  SWELRVEGKL LDDPSKQKRK FSSFFKSLVI ELDKDLYGPD NHLVEWHRTP TTQETDGFQV
   241  KRPGDLSVRC TLLLMLDYQP PQFKLDPRLA RLLGLHTQSR SAIVQALWQY VKTNRLQDSH
   301  DKEYINGDKY FQQIFDCPRL KFSEIPQRLT ALLLPPDPIV INHVISVDPS DQKKTACYDI
   361  DVEVEEPLKG QMSSFLLSTA NQQEISALDS KIHETIESIN QLKIQRDFML SFSRDPKGYV
   421  QDLLRSQSRD LKVMTDVAGN PEEERRAEFY HQPWSQEAVS RYFYCKIQQR RQELEQSLVV
   481  RNT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMARCD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
149 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 149 nTPM
  • cerebral cortex: 142 nTPM
  • amygdala: 128 nTPM
  • skeletal muscle: 121 nTPM
  • hypothalamus: 91 nTPM
  • hippocampal formation: 88 nTPM

Single-cell type

  • breast lactating cells: 160 nCPM
  • myonuclei: 136 nCPM
  • vascular smooth muscle cells: 121 nCPM
  • neutrophils: 107 nCPM
  • peritubular myoid cells: 107 nCPM
  • pericytes: 88 nCPM

Immune cell

  • classical monocyte: 5.5 nTPM
  • neutrophil: 1.9 nTPM
  • myeloid DC: 1.6 nTPM
  • intermediate monocyte: 1.3 nTPM
  • total PBMC: 1.3 nTPM
  • memory CD4 T-cell: 0.5 nTPM

Brain region

  • cerebral cortex: 116 nTPM
  • basal ganglia: 114 nTPM
  • hypothalamus: 106 nTPM
  • amygdala: 98 nTPM
  • midbrain: 88 nTPM
  • thalamus: 88 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.47
gnomAD pLI
0.4
gnomAD missense Z
2.58
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SMARCD3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMARCD3 as an antibody target. Whether an autoantibody or antibody against SMARCD3 could matter depends on whether native SMARCD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMARCD3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMARCD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMARCD3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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