Seroatlas · Human Serome Atlas

SMAP

Small acidic protein

Also known as: C11orf58, SMAP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00193
Gene
SMAP
Ensembl
ENSG00000110696
Chromosome
11
Canonical length
183 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Endoplasmic reticulum

OverviewNCBI Gene

No narrative summary is available for SMAP in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

183 residues, UniProt reviewed canonical sequence.

>O00193|SMAP
     1  MSAARESHPH GVKRSASPDD DLGSSNWEAA DLGNEERKQK FLRLMGAGKK EHTGRLVIGD
    61  HKSTSHFRTG EEDKKINEEL ESQYQQSMDS KLSGRYRRHC GLGFSEVEDH DGEGDVAGDD
   121  DDDDDDSPDP ESPDDSESDS ESEKEESAEE LQAAEHPDEV EDPKNKKDAK SNYKMMFVKS
   181  SGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMAP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
199 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 199 nTPM
  • ovary: 162 nTPM
  • esophagus: 162 nTPM
  • lymph node: 152 nTPM
  • thyroid gland: 152 nTPM
  • heart muscle: 150 nTPM

Single-cell type

  • syncytiotrophoblasts: 559 nCPM
  • oocytes: 539 nCPM
  • extravillous trophoblasts: 432 nCPM
  • early primary spermatocytes: 415 nCPM
  • migrating cytotrophoblasts: 410 nCPM
  • cytotrophoblasts: 365 nCPM

Immune cell

  • total PBMC: 898 nTPM
  • memory B-cell: 625 nTPM
  • basophil: 591 nTPM
  • naive B-cell: 583 nTPM
  • eosinophil: 555 nTPM
  • plasmacytoid DC: 546 nTPM

Brain region

  • white matter: 112 nTPM
  • choroid plexus: 111 nTPM
  • hypothalamus: 102 nTPM
  • medulla oblongata: 99 nTPM
  • basal ganglia: 90 nTPM
  • spinal cord: 90 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.74
gnomAD pLI
0.17
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMAP as an antibody target. Whether an autoantibody or antibody against SMAP could matter depends on whether native SMAP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMAP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMAP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMAP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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