SMAGP
Small cell adhesion glycoprotein
Also known as: hSMAGP, MGC149453, MGC149454, SMAGP_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q0VAQ4
- Gene
- SMAGP
- Ensembl
- ENSG00000170545
- Chromosome
- 12
- Canonical length
- 97 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Nucleoplasm,Plasma membrane,Cell Junctions
OverviewNCBI Gene
Located in cell junction; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
97 residues, UniProt reviewed canonical sequence.
>Q0VAQ4|SMAGP
1 MTSLLTTPSP REELMTTPIL QPTEALSPED GASTALIAVV ITVVFLTLLS VVILIFFYLY
61 KNKGSYVTYE PTEGEPSAIV QMESDLAKGS EKEEYFILocalizationUniProt · AlphaFold · HPA
Whether an antibody against SMAGP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.6
- Highest tissue expression
- 136 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 136 nTPM
- placenta: 96 nTPM
- vagina: 66 nTPM
- rectum: 57 nTPM
- colon: 54 nTPM
- cervix: 52 nTPM
Single-cell type
- cytotrophoblasts: 1,624 nCPM
- esophageal apical cells: 1,506 nCPM
- syncytiotrophoblasts: 901 nCPM
- migrating cytotrophoblasts: 561 nCPM
- esophageal suprabasal cells: 404 nCPM
- enteric transient amplifying cells: 144 nCPM
Immune cell
- naive B-cell: 39 nTPM
- memory B-cell: 37 nTPM
- NK-cell: 20 nTPM
- neutrophil: 16 nTPM
- gdT-cell: 15 nTPM
- eosinophil: 12 nTPM
Brain region
- cerebellum: 7.5 nTPM
- thalamus: 5.5 nTPM
- cerebral cortex: 5.3 nTPM
- choroid plexus: 5.1 nTPM
- hippocampal formation: 4.8 nTPM
- midbrain: 4.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.32
- gnomAD pLI
- 0.25
- gnomAD missense Z
- -0.03
- DepMap mean gene effect
- -0.23
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Small cell adhesion glycoprotein
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SMAGP as an antibody target. Whether an autoantibody or antibody against SMAGP could matter depends on whether native SMAGP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SMAGP is annotated at the cell surface, where native SMAGP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label SMAGP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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