Seroatlas · Human Serome Atlas

SLX4IP

Protein SLX4IP

Also known as: C20orf94, dJ1099D15.3, SLX4I_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VYV7
Gene: SLX4IP
Ensembl: ENSG00000149346
Chromosome: 20
Canonical length: 408 aa
Protein class: Disease related genes, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

No narrative summary is available for SLX4IP in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

408 residues, UniProt reviewed canonical sequence.

>Q5VYV7|SLX4IP
     1  MASKKFAVKC GNFAVLVDLH ILPQGSNKDT SWFSEQKKEE VCLLLKETID SRVQEYLEVR
    61  KQHRPSNAEF TRSNPLSLKG YGFQITAYFL KRGIRLRCIR STQNAELCVF PDRFVVCVSQ
   121  LAFSRDLLAS QNEDLTERVL HGVSDYFAEC AESSLPPSAK LRRNALKEIV KRTETKSSVT
   181  SKSQTRRDTV ETSSDSVIAE IARRRNDGQA SSSPPSESMG QAKDSIKAAE SHWGLPVQKL
   241  EKVNQTQPED TSGQQKPHPG ERLKTGLLSR SPVCSCESAS PCPKQSPRVA KTQQKRRNCS
   301  SAEDFDHHGR VSLGSDRLVP REIIVEKSKA VRVLPASELS DPGLLLKQDL AKTTSKEELH
   361  VLESLSSRHL MKNNPGQAQQ TGLATNTERL STIQNSPTKK RKKYERGH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLX4IP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 4.9 nTPM

Expression across tissuesHPA

Tissue

retina: 4.9 nTPM
epididymis: 4.5 nTPM
pituitary gland: 4.4 nTPM
skeletal muscle: 3.9 nTPM
skin: 3.5 nTPM
parathyroid gland: 3.1 nTPM

Single-cell type

somatotrophs: 269 nCPM
thyrotrophs: 252 nCPM
lactotrophs: 236 nCPM
sertoli cells: 216 nCPM
corticotrophs: 213 nCPM
pituitary stem cells: 204 nCPM

Immune cell

plasmacytoid DC: 2 nTPM
non-classical monocyte: 1.7 nTPM
T-reg: 1.5 nTPM
intermediate monocyte: 1.3 nTPM
NK-cell: 1.3 nTPM
MAIT T-cell: 1.2 nTPM

Brain region

white matter: 8.4 nTPM
hypothalamus: 8 nTPM
medulla oblongata: 7.7 nTPM
pons: 7.6 nTPM
basal ganglia: 7.5 nTPM
midbrain: 7.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.49
gnomAD pLI: 0
gnomAD missense Z: 0.33
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Protein SLX4IP
Uncharacterized protein family UPF0492

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLX4IP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SLX4

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLX4IP as an antibody target. Whether an autoantibody or antibody against SLX4IP could matter depends on whether native SLX4IP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLX4IP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLX4IP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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