SLX1A

Protein identityUniProt · HPA

UniProt accession

Q9BQ83

Gene

SLX1A

Ensembl

ENSG00000132207

Chromosome

16

Canonical length

275 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more telomeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A4 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4) gene. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

275 residues, UniProt reviewed canonical sequence.

>Q9BQ83|SLX1A
     1  MGPAGVAARP GRFFGVYLLY CLNPRYRGRV YVGFTVNTAR RVQQHNGGRK KGGAWRTSGR
    61  GPWEMVLVVH GFPSSVAALR FEWAWQHPHA SRRLAHVGPR LRGETAFAFH LRVLAHMLRA
   121  PPWARLPLTL RWVRPDLRQD LCLPPPPHVP LAFGPPPPQA PAPRRRAGPF DDAEPEPDQG
   181  DPGACCSLCA QTIQDEEGPL CCPHPGCLLR AHVICLAEEF LQEEPGQLLP LEGQCPCCEK
   241  SLLWGDLIWL CQMDTEKEVE DSELEEAHWT DLLET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLX1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.35

Highest tissue expression

83 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.16

gnomAD pLI

0.12

gnomAD missense Z

1.38

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• DNA double-strand break processing involved in repair via single-strand annealing
• DNA repair
• double-strand break repair via homologous recombination
• negative regulation of telomere maintenance via telomere lengthening
• positive regulation of t-circle formation
• t-circle formation
• telomere maintenance via telomere lengthening
• telomeric D-loop disassembly

Molecular functions

• 5'-flap endonuclease activity
• crossover junction DNA endonuclease activity
• zinc ion binding

Cellular components

• nucleoplasm
• Slx1-Slx4 complex

Protein domainsUniProt · Pfam · InterPro

• GIY-YIG endonuclease
• Zinc finger, RING/FYVE/PHD-type
• Structure-specific endonuclease subunit Slx1
• GIY-YIG endonuclease superfamily
• Structure-specific endonuclease subunit SLX1, C-terminal domain
• SLX1 structure-specific endonuclease
• GIY-YIG catalytic domain
• Structure-specific endonuclease subunit SLX1, C-terminal

KeywordsUniProt

• DNA damage
• DNA recombination
• DNA repair
• Endonuclease
• Hydrolase
• Metal-binding
• Nuclease
• Nucleus
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of SLX1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ERCC4
• SLX4