Seroatlas · Human Serome Atlas

SLURP1

Secreted Ly-6/uPAR-related protein 1

Also known as: ANUP, ARS, ArsB, LY6-MT, LY6LS, MDM, SLUR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P55000
Gene
SLURP1
Ensembl
ENSG00000126233
Chromosome
8
Canonical length
103 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted secreted proteins, Transporters
Secretome location
Secreted in other tissues
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

103 residues, UniProt reviewed canonical sequence.

>P55000|SLURP1
     1  MASRWAVQLL LVAAWSMGCG EALKCYTCKE PMTSASCRTI TRCKPEDTAC MTTLVTVEAE
    61  YPFNQSPVVT RSCSSSCVAT DPDSIGAAHL IFCCFRDLCN SEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLURP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
1,037 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 1,037 nTPM
  • skin: 855 nTPM
  • vagina: 195 nTPM
  • cervix: 146 nTPM
  • salivary gland: 65 nTPM
  • tonsil: 16 nTPM

Single-cell type

  • esophageal apical cells: 29,388 nCPM
  • esophageal suprabasal cells: 2,800 nCPM
  • suprabasal keratinocytes: 1,512 nCPM
  • ocular epithelial cells: 38 nCPM
  • esophageal basal cells: 35 nCPM
  • schwann cells: 17 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 2.7 nTPM
  • cerebral cortex: 1.9 nTPM
  • thalamus: 1.5 nTPM
  • hippocampal formation: 1.4 nTPM
  • pons: 1.3 nTPM
  • basal ganglia: 1.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLURP1.

Disease | AllUniProt

Conditions SLURP1 is implicated in, by any mechanism.

Disease | GeneticClinVar

15 pathogenic / likely-pathogenic of 48 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Acroerythrokeratoderma

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.31
gnomAD pLI
0.26
gnomAD missense Z
0.59
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLURP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLURP1 as an antibody target. Whether an autoantibody or antibody against SLURP1 could matter depends on whether native SLURP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLURP1 is annotated as secreted, so native SLURP1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SLURP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLURP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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