Seroatlas · Human Serome Atlas

SLITRK4

SLIT and NTRK-like protein 4

Also known as: DKFZp547M2010, SLIK4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IW52
Gene
SLITRK4
Ensembl
ENSG00000179542
Chromosome
X
Canonical length
837 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a transmembrane protein belonging to the the SLITRK family. These family members include two N-terminal leucine-rich repeat domains similar to those found in the axonal growth-controlling protein SLIT, as well as C-terminal regions similar to neurotrophin receptors. Studies of an homologous protein in mouse suggest that this family member functions to suppress neurite outgrowth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

837 residues, UniProt reviewed canonical sequence.

>Q8IW52|SLITRK4
     1  MFLWLFLILS ALISSTNADS DISVEICNVC SCVSVENVLY VNCEKVSVYR PNQLKPPWSN
    61  FYHLNFQNNF LNILYPNTFL NFSHAVSLHL GNNKLQNIEG GAFLGLSALK QLHLNNNELK
   121  ILRADTFLGI ENLEYLQADY NLIKYIERGA FNKLHKLKVL ILNDNLISFL PDNIFRFASL
   181  THLDIRGNRI QKLPYIGVLE HIGRVVELQL EDNPWNCSCD LLPLKAWLEN MPYNIYIGEA
   241  ICETPSDLYG RLLKETNKQE LCPMGTGSDF DVRILPPSQL ENGYTTPNGH TTQTSLHRLV
   301  TKPPKTTNPS KISGIVAGKA LSNRNLSQIV SYQTRVPPLT PCPAPCFCKT HPSDLGLSVN
   361  CQEKNIQSMS ELIPKPLNAK KLHVNGNSIK DVDVSDFTDF EGLDLLHLGS NQITVIKGDV
   421  FHNLTNLRRL YLNGNQIERL YPEIFSGLHN LQYLYLEYNL IKEISAGTFD SMPNLQLLYL
   481  NNNLLKSLPV YIFSGAPLAR LNLRNNKFMY LPVSGVLDQL QSLTQIDLEG NPWDCTCDLV
   541  ALKLWVEKLS DGIVVKELKC ETPVQFANIE LKSLKNEILC PKLLNKPSAP FTSPAPAITF
   601  TTPLGPIRSP PGGPVPLSIL ILSILVVLIL TVFVAFCLLV FVLRRNKKPT VKHEGLGNPD
   661  CGSMQLQLRK HDHKTNKKDG LSTEAFIPQT IEQMSKSHTC GLKESETGFM FSDPPGQKVV
   721  MRNVADKEKD LLHVDTRKRL STIDELDELF PSRDSNVFIQ NFLESKKEYN SIGVSGFEIR
   781  YPEKQPDKKS KKSLIGGNHS KIVVEQRKSE YFELKAKLQS SPDYLQVLEE QTALNKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLITRK4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
9.8 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 9.8 nTPM
  • cerebellum: 9.6 nTPM
  • skeletal muscle: 7.1 nTPM
  • cerebral cortex: 6.7 nTPM
  • cervix: 4.8 nTPM
  • hippocampal formation: 4.4 nTPM

Single-cell type

  • adrenal cortex cells: 79 nCPM
  • leydig cells: 64 nCPM
  • brain excitatory neurons: 49 nCPM
  • brain inhibitory neurons: 47 nCPM
  • oligodendrocyte progenitor cells: 36 nCPM
  • thymic myoid cells: 33 nCPM

Immune cell

  • basophil: 12 nTPM
  • classical monocyte: 4.1 nTPM
  • myeloid DC: 3.2 nTPM
  • non-classical monocyte: 2.7 nTPM
  • intermediate monocyte: 2.5 nTPM
  • total PBMC: 0.9 nTPM

Brain region

  • cerebellum: 32 nTPM
  • cerebral cortex: 31 nTPM
  • basal ganglia: 26 nTPM
  • hippocampal formation: 23 nTPM
  • hypothalamus: 17 nTPM
  • white matter: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.42
gnomAD pLI
0.79
gnomAD missense Z
1.97
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLITRK4 as an antibody target. Whether an autoantibody or antibody against SLITRK4 could matter depends on whether native SLITRK4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLITRK4 is annotated at the cell surface, where native SLITRK4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLITRK4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLITRK4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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