Seroatlas · Human Serome Atlas

SLC9C2

Sodium/hydrogen exchanger 11

Also known as: MGC43026, SL9C2_HUMAN, SLC9A11

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TAH2
Gene: SLC9C2
Ensembl: ENSG00000162753
Chromosome: 1
Canonical length: 1124 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nuclear speckles,Plasma membrane

OverviewNCBI Gene

Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1124 residues, UniProt reviewed canonical sequence.

>Q5TAH2|SLC9C2
     1  MSSYFWAQNE SNRPDLLCGQ PADYLVEEKH FTTLVCFIVV LGGLLKMCLK NCEVIVLTIL
    61  SLSGFVIGHM AYNSVEVHQI VYPLLRTSSF SLYSYFSPLI IFMVALDVEF YTLKKMFWQV
   121  LLTGLISFST ASIIIGYVVI KFNKDSWDLQ SCLLFSITLG IIDPLRSVNS LKTIGISKIY
   181  IDLIRGESLI ICSIASIFFG NFRGNRIHFS IFRDLHVGIE LSYDILGSII FGYWCAKIIQ
   241  CILADVFSNM LTNIILCFSM VYMTFYIVEF LGMSGTLALA AVGLNLDSLT FKPKIELVIT
   301  KFLRIFSSVY EHLIYAFFGI VIGCGELSHY EFHTIPFIFI LFTTVNLVRL LTILLVSPIL
   361  MHSNYEYNWR WGVVITWSGI KGVFNLLWAP DVYNLAERKV EVPQMFILYV QVISLLTMGI
   421  NSYVMTQSAR KLDLCVLSLP RQMILQNATQ HIQEIVQNTI TLFKTEKILT NVNWTLVEDK
   481  TRIEYIPFSH VSHNDMKTES TTDEALMEEA RLHVAAIQMS SFEKQRNNGI LEIEAARILI
   541  GAAKCYYSIQ GKFMSIYDVS TYMRTRSWLI KFKNVLTFLE YCIEKIHFIP PESNTFLTFI
   601  FHIVFSEEFE YTGQIINLIY IYPMIIHLWP MARGLNVSAL ISINYYFMFL YVLESTLKII
   661  ILKRKYFQQC WNTLEFFILV IGIIDIFCVY FVKLRPDNLA LIQLTVIMGY LRIIRFLPLF
   721  KIIVPILIRI ADVQIKKRLS LMYSITKGYI KSQEDAKLLI KQIAVCESIY QKLCEILETN
   781  KQDAVKELVL MEHEGRDVVI ALKTKQAIRN VIAKALKNLT FLCSRGIIDK HEVIEINKVL
   841  LKKLKALNNF PKAIPPPTPD IYLHNIIWLE GKDVLIDFFK ERAKLACFDS GDTICKGGEM
   901  PQGIYLIISG MAILHSLSPT FGIESNQRCD RGSRDMFTEF CTTGDIIGEL SCLLKREIEY
   961  TVICETSLQA CFISLEDLYE GFDAFWPSLE YKIWLKLALS TAYQYFESSL IDEDLRFQNC
  1021  VMFNQAYVET LSSYSDMIID NMTMKFVIIV YGSVIDTKTE EPYFAPCIIP TTCEQVQGTS
  1081  DLSKLLIIQA SELTQRNSNT NVMASVNTVF EQPGKNINGR QKMS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC9C2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 15
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 5.6 nTPM

Expression across tissuesHPA

Tissue

testis: 5.6 nTPM
choroid plexus: 0.7 nTPM
fallopian tube: 0.5 nTPM
retina: 0.3 nTPM
ovary: 0.2 nTPM
basal ganglia: 0.1 nTPM

Single-cell type

ependymal cells: 326 nCPM
respiratory ciliated cells: 122 nCPM
sertoli cells: 121 nCPM
cone photoreceptor cells: 95 nCPM
choroid plexus epithelial cells: 78 nCPM
fallopian tube ciliated cells: 45 nCPM

Immune cell

plasmacytoid DC: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

choroid plexus: 4.5 nTPM
medulla oblongata: 3.4 nTPM
midbrain: 3 nTPM
spinal cord: 2.2 nTPM
white matter: 1.7 nTPM
basal ganglia: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.46
gnomAD pLI: 0
gnomAD missense Z: 2.01
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC9C2 as an antibody target. Whether an autoantibody or antibody against SLC9C2 could matter depends on whether native SLC9C2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC9C2 is annotated at the cell surface, where native SLC9C2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC9C2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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