Seroatlas · Human Serome Atlas

SLC9B2

Sodium/hydrogen exchanger 9B2

Also known as: FLJ23984, NHA2, NHEDC2, SL9B2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86UD5
Gene
SLC9B2
Ensembl
ENSG00000164038
Chromosome
4
Canonical length
537 aa
Protein class
Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Cell Junctions
Quaternary structure
Homodimer

OverviewNCBI Gene

Sodium hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain or the F1F0 mitochondrial ATPase into sodium gradients that drive other energy-requiring processes, transduce environmental signals into cell responses, or function in drug efflux (Xiang et al., 2007 [PubMed 18000046]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

537 residues, UniProt reviewed canonical sequence.

>Q86UD5|SLC9B2
     1  MGDEDKRITY EDSEPSTGMN YTPSMHQEAQ EETVMKLKGI DANEPTEGSI LLKSSEKKLQ
    61  ETPTEANHVQ RLRQMLACPP HGLLDRVITN VTIIVLLWAV VWSITGSECL PGGNLFGIII
   121  LFYCAIIGGK LLGLIKLPTL PPLPSLLGML LAGFLIRNIP VINDNVQIKH KWSSSLRSIA
   181  LSIILVRAGL GLDSKALKKL KGVCVRLSMG PCIVEACTSA LLAHYLLGLP WQWGFILGFV
   241  LGAVSPAVVV PSMLLLQGGG YGVEKGVPTL LMAAGSFDDI LAITGFNTCL GIAFSTGSTV
   301  FNVLRGVLEV VIGVATGSVL GFFIQYFPSR DQDKLVCKRT FLVLGLSVLA VFSSVHFGFP
   361  GSGGLCTLVM AFLAGMGWTS EKAEVEKIIA VAWDIFQPLL FGLIGAEVSI ASLRPETVGL
   421  CVATVGIAVL IRILTTFLMV CFAGFNLKEK IFISFAWLPK ATVQAAIGSV ALDTARSHGE
   481  KQLEDYGMDV LTVAFLSILI TAPIGSLLIG LLGPRLLQKV EHQNKDEEVQ GETSVQV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC9B2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
14
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • liver: 36 nTPM
  • cerebral cortex: 20 nTPM
  • cerebellum: 18 nTPM
  • hypothalamus: 12 nTPM
  • retina: 12 nTPM
  • spinal cord: 9.6 nTPM

Single-cell type

  • smooth muscle cells: 134 nCPM
  • cone photoreceptor cells: 89 nCPM
  • hepatocytes: 80 nCPM
  • adrenal medulla cells: 75 nCPM
  • thyrotrophs: 67 nCPM
  • brain excitatory neurons: 66 nCPM

Immune cell

  • NK-cell: 12 nTPM
  • MAIT T-cell: 6.4 nTPM
  • memory CD4 T-cell: 5.2 nTPM
  • memory B-cell: 5.1 nTPM
  • gdT-cell: 4.9 nTPM
  • memory CD8 T-cell: 4.1 nTPM

Brain region

  • pons: 33 nTPM
  • cerebral cortex: 33 nTPM
  • basal ganglia: 31 nTPM
  • hypothalamus: 30 nTPM
  • white matter: 29 nTPM
  • cerebellum: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.85
gnomAD pLI
0
gnomAD missense Z
-0.05
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC9B2 as an antibody target. Whether an autoantibody or antibody against SLC9B2 could matter depends on whether native SLC9B2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC9B2 is annotated at the cell surface, where native SLC9B2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC9B2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC9B2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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