Seroatlas · Human Serome Atlas

SLC9B1P1

Putative SLC9B1-like protein SLC9B1P1

Also known as: SL9P1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NJY1
Gene: SLC9B1P1
Canonical length: 282 aa

OverviewNCBI Gene

No narrative summary is available for SLC9B1P1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

282 residues, UniProt reviewed canonical sequence.

>A6NJY1|SLC9B1P1
     1  MVLQENGYGV EEDIPTLLMA ASSMDDLLAI TGFNTCLSIV FYSGGMINNA IASLRNVCIS
    61  LLAGIVLGFF VRYFPSEDQK KITLKRGFLV LITFVSAVLG SQPIGLHGSG GLCTLVLHFI
   121  EWTKWSQEKM KVQKIITNVW DIFQPLLFGL VGAEVSVSLL ESNIVGISVS TLSLALCVRI
   181  LNIYLLMCFA GFSFKEKIFI ALAWMPKATV QAVLGPLALE TARVSTPHLE TYAKDVMTVA
   241  FLAIMITAPN GALLMGILGP KMLTRHYDPS KIKLQLSTLE HH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC9B1P1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.32

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
gnomAD missense Z: -1.68

OntologyGO

Biological processes

Molecular functions

antiporter activity

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC9B1P1 as an antibody target. Whether an autoantibody or antibody against SLC9B1P1 could matter depends on whether native SLC9B1P1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC9B1P1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC9B1P1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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