Seroatlas · Human Serome Atlas

SLC9B1

Sodium/hydrogen exchanger 9B1

Also known as: NHA1, NHEDC1, SL9B1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q4ZJI4
Gene: SLC9B1
Ensembl: ENSG00000164037
Chromosome: 4
Canonical length: 515 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Cytosol,Acrosome,Principal piece

OverviewNCBI Gene

The protein encoded by this gene is a sodium/hydrogen exchanger and transmembrane protein. Highly conserved orthologs of this gene have been found in other mammalian species. The expression of this gene may be limited to testis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Canonical amino-acid sequenceUniProt

515 residues, UniProt reviewed canonical sequence.

>Q4ZJI4|SLC9B1
     1  MHTTESKNEH LEDENFQTST TPQSLIDPNN TAQEETKTVL SDTEEIKPQT KKETYISCPL
    61  RGVLNVIITN GVILFVIWCM TWSILGSEAL PGGNLFGLFI IFYSAIIGGK ILQLIRIPLV
   121  PPLPPLLGML LAGFTIRNVP FINEHVHVPN TWSSILRSIA LTIILIRAGL GLDPQALRHL
   181  KVVCFRLAVG PCLMEASAAA VFSHFIMKFP WQWAFLLGFV LGAVSPAVVV PYMMVLQENG
   241  YGVEEGIPTL LMAASSMDDI LAITGFNTCL SIVFSSGGIL NNAIASIRNV CISLLAGIVL
   301  GFFVRYFPSE DQKKLTLKRG FLVLTMCVSA VLGSQRIGLH GSGGLCTLVL SFIAGTKWSQ
   361  EKMKVQKIIT TVWDIFQPLL FGLVGAEVSV SSLESNIVGI SVATLSLALC VRILTTYLLM
   421  CFAGFSFKEK IFIALAWMPK ATVQAVLGPL ALETARVSAP HLEPYAKDVM TVAFLAILIT
   481  APNGALLMGI LGPKMLTRHY DPSKIKLQLS TLEHH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC9B1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

testis: 38 nTPM
epididymis: 2 nTPM
skin: 1.7 nTPM
retina: 1.6 nTPM
gallbladder: 1.4 nTPM
endometrium: 1.3 nTPM

Single-cell type

late primary spermatocytes: 507 nCPM
late spermatids: 155 nCPM
early spermatids: 138 nCPM
early primary spermatocytes: 100 nCPM
bergmann glia: 59 nCPM
oligodendrocytes: 46 nCPM

Immune cell

naive CD4 T-cell: 1.5 nTPM
naive CD8 T-cell: 0.9 nTPM
plasmacytoid DC: 0.7 nTPM
memory CD8 T-cell: 0.6 nTPM
T-reg: 0.6 nTPM
MAIT T-cell: 0.5 nTPM

Brain region

white matter: 12 nTPM
pons: 9.6 nTPM
basal ganglia: 8.7 nTPM
medulla oblongata: 8.7 nTPM
spinal cord: 8.7 nTPM
midbrain: 8.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC9B1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 71 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Usher syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: 0.87
DepMap mean gene effect: -0.41
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

sodium:proton antiporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC9B1 as an antibody target. Whether an autoantibody or antibody against SLC9B1 could matter depends on whether native SLC9B1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC9B1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC9B1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...