Seroatlas · Human Serome Atlas

SLC9A8

Sodium/hydrogen exchanger 8

Also known as: KIAA0939, NHE8, SL9A8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2E8
Gene: SLC9A8
Ensembl: ENSG00000197818
Chromosome: 20
Canonical length: 581 aa
Protein class: Metabolic proteins, Plasma proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Sodium-hydrogen exchangers (NHEs), such as SLC9A8, are integral transmembrane proteins that exchange extracellular Na+ for intracellular H+. NHEs have multiple functions, including intracellular pH homeostasis, cell volume regulation, and electroneutral NaCl absorption in epithelia (Xu et al., 2008 [PubMed 18209477]).[supplied by OMIM, Apr 2009]

Canonical amino-acid sequenceUniProt

581 residues, UniProt reviewed canonical sequence.

>Q9Y2E8|SLC9A8
     1  MGEKMAEEER FPNTTHEGFN VTLHTTLVVT TKLVLPTPGK PILPVQTGEQ AQQEEQSSGM
    61  TIFFSLLVLA ICIILVHLLI RYRLHFLPES VAVVSLGILM GAVIKIIEFK KLANWKEEEM
   121  FRPNMFFLLL LPPIIFESGY SLHKGNFFQN IGSITLFAVF GTAISAFVVG GGIYFLGQAD
   181  VISKLNMTDS FAFGSLISAV DPVATIAIFN ALHVDPVLNM LVFGESILND AVSIVLTNTA
   241  EGLTRKNMSD VSGWQTFLQA LDYFLKMFFG SAALGTLTGL ISALVLKHID LRKTPSLEFG
   301  MMIIFAYLPY GLAEGISLSG IMAILFSGIV MSHYTHHNLS PVTQILMQQT LRTVAFLCET
   361  CVFAFLGLSI FSFPHKFEIS FVIWCIVLVL FGRAVNIFPL SYLLNFFRDH KITPKMMFIM
   421  WFSGLRGAIP YALSLHLDLE PMEKRQLIGT TTIVIVLFTI LLLGGSTMPL IRLMDIEDAK
   481  AHRRNKKDVN LSKTEKMGNT VESEHLSELT EEEYEAHYIR RQDLKGFVWL DAKYLNPFFT
   541  RRLTQEDLHH GRIQMKTLTN KWYEEVRQGP SGSEDDEQEL L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC9A8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 11
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 19 nTPM
skeletal muscle: 10 nTPM
esophagus: 7.9 nTPM
spleen: 7.3 nTPM
stomach: 7.2 nTPM
appendix: 6.6 nTPM

Single-cell type

neutrophils: 958 nCPM
neutrophil progenitors: 346 nCPM
monocytes: 163 nCPM
monocyte progenitors: 117 nCPM
myonuclei: 103 nCPM
endometrial glandular cells: 102 nCPM

Immune cell

neutrophil: 3 nTPM
basophil: 1.9 nTPM
eosinophil: 1.6 nTPM
gdT-cell: 0.9 nTPM
MAIT T-cell: 0.9 nTPM
memory CD8 T-cell: 0.8 nTPM

Brain region

medulla oblongata: 16 nTPM
hypothalamus: 14 nTPM
midbrain: 14 nTPM
spinal cord: 13 nTPM
thalamus: 13 nTPM
pons: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.01
gnomAD pLI: 0
gnomAD missense Z: 1.62
DepMap mean gene effect: 0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC9A8 as an antibody target. Whether an autoantibody or antibody against SLC9A8 could matter depends on whether native SLC9A8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC9A8 is annotated at the cell surface, where native SLC9A8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC9A8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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