Seroatlas · Human Serome Atlas

SLC7A8

Large neutral amino acids transporter small subunit 2

Also known as: LAT2, LAT2_HUMAN, LPI-PC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UHI5
Gene
SLC7A8
Ensembl
ENSG00000092068
Chromosome
14
Canonical length
535 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Enables several functions, including neutral L-amino acid transmembrane transporter activity; protein heterodimerization activity; and secondary active transmembrane transporter activity. Involved in L-alanine import across plasma membrane; L-leucine import across plasma membrane; and thyroid hormone transport. Located in basolateral plasma membrane and microvillus membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

535 residues, UniProt reviewed canonical sequence.

>Q9UHI5|SLC7A8
     1  MEEGARHRNN TEKKHPGGGE SDASPEAGSG GGGVALKKEI GLVSACGIIV GNIIGSGIFV
    61  SPKGVLENAG SVGLALIVWI VTGFITVVGA LCYAELGVTI PKSGGDYSYV KDIFGGLAGF
   121  LRLWIAVLVI YPTNQAVIAL TFSNYVLQPL FPTCFPPESG LRLLAAICLL LLTWVNCSSV
   181  RWATRVQDIF TAGKLLALAL IIIMGIVQIC KGEYFWLEPK NAFENFQEPD IGLVALAFLQ
   241  GSFAYGGWNF LNYVTEELVD PYKNLPRAIF ISIPLVTFVY VFANVAYVTA MSPQELLASN
   301  AVAVTFGEKL LGVMAWIMPI SVALSTFGGV NGSLFTSSRL FFAGAREGHL PSVLAMIHVK
   361  RCTPIPALLF TCISTLLMLV TSDMYTLINY VGFINYLFYG VTVAGQIVLR WKKPDIPRPI
   421  KINLLFPIIY LLFWAFLLVF SLWSEPVVCG IGLAIMLTGV PVYFLGVYWQ HKPKCFSDFI
   481  ELLTLVSQKM CVVVYPEVER GSGTEEANED MEEQQQPMYQ PTPTKDKDVA GQPQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC7A8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
11
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
311 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 311 nTPM
  • kidney: 111 nTPM
  • stomach: 60 nTPM
  • ovary: 58 nTPM
  • endometrium: 43 nTPM
  • skeletal muscle: 42 nTPM

Single-cell type

  • podocytes: 396 nCPM
  • epicardial cells: 334 nCPM
  • proximal tubule cells: 240 nCPM
  • kupffer cells: 188 nCPM
  • thymic myoid cells: 137 nCPM
  • mesothelial cells: 128 nCPM

Immune cell

  • eosinophil: 12 nTPM
  • basophil: 8.3 nTPM
  • naive CD8 T-cell: 2.9 nTPM
  • total PBMC: 1.7 nTPM
  • MAIT T-cell: 1 nTPM
  • naive CD4 T-cell: 0.9 nTPM

Brain region

  • choroid plexus: 113 nTPM
  • thalamus: 37 nTPM
  • cerebral cortex: 37 nTPM
  • basal ganglia: 36 nTPM
  • pons: 34 nTPM
  • cerebellum: 33 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC7A8.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 92 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.99
gnomAD pLI
0
gnomAD missense Z
0.17
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC7A8 as an antibody target. Whether an autoantibody or antibody against SLC7A8 could matter depends on whether native SLC7A8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC7A8 is annotated at the cell surface, where native SLC7A8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC7A8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC7A8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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