Seroatlas · Human Serome Atlas

SLC7A6OS

Probable RNA polymerase II nuclear localization protein SLC7A6OS

Also known as: FLJ13291, Iwr1, S7A6O_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96CW6
Gene
SLC7A6OS
Ensembl
ENSG00000103061
Chromosome
16
Canonical length
309 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to be involved in developmental process. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in cytoplasm and nucleus. Implicated in progressive myoclonus epilepsy. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>Q96CW6|SLC7A6OS
     1  MEAARTAVLR VKRKRSAEPA EALVLACKRL RSDAVESAAQ KTSEGLERAA ENNVFHLVAT
    61  VCSQEEPVQP LLREVLRPSR DSQQRVRRNL RASAREVRQE GRYRVLSSRR SLGTTSSGQE
   121  SEYTPGNPEA AGNSGFQLLD LVHEEGEPEA ASAGSCKTSD PDVILCNSVE LIRERLTVSE
   181  DGPGVRRQEE QKHDDYVYDI YYLETATPGW IENILSVQPY SQEWELVNDD QEPEDIYDDE
   241  DDENSENNWR NEYPEEESSD GDEDSRGSAD YNSLSEEERG SSRQRMWSKY PLDVQKEFGY
   301  DSPHDLDSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC7A6OS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 17 nTPM
  • lymph node: 15 nTPM
  • adipose tissue: 14 nTPM
  • bone marrow: 13 nTPM
  • heart muscle: 13 nTPM
  • spleen: 13 nTPM

Single-cell type

  • cardiomyocytes: 636 nCPM
  • adipocytes: 320 nCPM
  • thymic myoid cells: 280 nCPM
  • myonuclei: 156 nCPM
  • epicardial cells: 73 nCPM
  • fibro-adipogenic progenitors: 49 nCPM

Immune cell

  • basophil: 29 nTPM
  • eosinophil: 26 nTPM
  • MAIT T-cell: 17 nTPM
  • T-reg: 16 nTPM
  • naive CD4 T-cell: 16 nTPM
  • naive B-cell: 15 nTPM

Brain region

  • white matter: 20 nTPM
  • cerebellum: 18 nTPM
  • medulla oblongata: 17 nTPM
  • basal ganglia: 17 nTPM
  • pons: 17 nTPM
  • midbrain: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC7A6OS.

Disease | AllUniProt

Conditions SLC7A6OS is implicated in, by any mechanism.

  • Epilepsy, progressive myoclonic 12 (EPM12) MIM:619191

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.61
gnomAD pLI
0.17
gnomAD missense Z
0.18
DepMap mean gene effect
-1.02
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Transcription factor Iwr1 domain
  • Probable RNA polymerase II nuclear localization protein SLC7A6OS
  • Transcription factor Iwr1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC7A6OS as an antibody target. Whether an autoantibody or antibody against SLC7A6OS could matter depends on whether native SLC7A6OS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC7A6OS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC7A6OS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC7A6OS. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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