Seroatlas · Human Serome Atlas

SLC7A4

Cationic amino acid transporter 4

Also known as: CAT-4, CTR4_HUMAN, HCAT3, VH

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43246
Gene
SLC7A4
Ensembl
ENSG00000099960
Chromosome
22
Canonical length
635 aa
Protein class
Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Vesicles,Plasma membrane

OverviewNCBI Gene

Predicted to enable amino acid transmembrane transporter activity. Predicted to be involved in amino acid transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

635 residues, UniProt reviewed canonical sequence.

>O43246|SLC7A4
     1  MARGLPTIAS LARLCQKLNR LKPLEDSTME TSLRRCLSTL DLTLLGVGGM VGSGLYVLTG
    61  AVAKEVAGPA VLLSFGVAAV ASLLAALCYA EFGARVPRTG SAYLFTYVSM GELWAFLIGW
   121  NVLLEYIIGG AAVARAWSGY LDSMFSHSIR NFTETHVGSW QVPLLGHYPD FLAAGIILLA
   181  SAFVSCGARV SSWLNHTFSA ISLLVILFIV ILGFILAQPH NWSADEGGFA PFGFSGVMAG
   241  TASCFYAFVG FDVIAASSEE AQNPRRSVPL AIAISLAIAA GAYILVSTVL TLMVPWHSLD
   301  PDSALADAFY QRGYRWAGFI VAAGSICAMN TVLLSLLFSL PRIVYAMAAD GLFFQVFAHV
   361  HPRTQVPVAG TLAFGLLTAF LALLLDLESL VQFLSLGTLL AYTFVATSII VLRFQKSSPP
   421  SSPGPASPGP LTKQQSSFSD HLQLVGTVHA SVPEPGELKP ALRPYLGFLD GYSPGAVVTW
   481  ALGVMLASAI TIGCVLVFGN STLHLPHWGY ILLLLLTSVM FLLSLLVLGA HQQQYREDLF
   541  QIPMVPLIPA LSIVLNICLM LKLSYLTWVR FSIWLLMGLA VYFGYGIRHS KENQRELPGL
   601  NSTHYVVFPR GSLEETVQAM QPPSQAPAQD PGHME

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC7A4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
13
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • testis: 15 nTPM
  • choroid plexus: 13 nTPM
  • hypothalamus: 5.6 nTPM
  • esophagus: 5.4 nTPM
  • cerebellum: 4.9 nTPM
  • pituitary gland: 4.5 nTPM

Single-cell type

  • other brain neurons: 5.7 nCPM
  • endometrial luminal cells: 2.8 nCPM
  • brain excitatory neurons: 2.7 nCPM
  • epicardial cells: 2.3 nCPM
  • brain inhibitory neurons: 1.8 nCPM
  • choroid plexus epithelial cells: 1.1 nCPM

Immune cell

  • MAIT T-cell: 0.5 nTPM
  • naive CD8 T-cell: 0.4 nTPM
  • memory CD8 T-cell: 0.2 nTPM
  • NK-cell: 0.2 nTPM
  • total PBMC: 0.1 nTPM
  • basophil: 0 nTPM

Brain region

  • pons: 15 nTPM
  • choroid plexus: 14 nTPM
  • hypothalamus: 14 nTPM
  • cerebellum: 13 nTPM
  • basal ganglia: 12 nTPM
  • midbrain: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.23
gnomAD pLI
0
gnomAD missense Z
0.07
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC7A4 as an antibody target. Whether an autoantibody or antibody against SLC7A4 could matter depends on whether native SLC7A4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC7A4 is annotated at the cell surface, where native SLC7A4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC7A4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC7A4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...