Seroatlas · Human Serome Atlas

SLC7A3

Cationic amino acid transporter 3

Also known as: ATRC3, CAT-3, CTR3_HUMAN, FLJ14541

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WY07
Gene: SLC7A3
Ensembl: ENSG00000165349
Chromosome: X
Canonical length: 619 aa
Protein class: FDA approved drug targets, Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of the solute carrier family 7. The encoded protein is a sodium-independent cationic amino acid transporter. Alternate splicing results in multiple transcripts that encoded the same protein.[provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

619 residues, UniProt reviewed canonical sequence.

>Q8WY07|SLC7A3
     1  MPWQAFRRFG QKLVRRRTLE SGMAETRLAR CLSTLDLVAL GVGSTLGAGV YVLAGEVAKD
    61  KAGPSIVICF LVAALSSVLA GLCYAEFGAR VPRSGSAYLY SYVTVGELWA FTTGWNLILS
   121  YVIGTASVAR AWSSAFDNLI GNHISKTLQG SIALHVPHVL AEYPDFFALG LVLLLTGLLA
   181  LGASESALVT KVFTGVNLLV LGFVMISGFV KGDVHNWKLT EEDYELAMAE LNDTYSLGPL
   241  GSGGFVPFGF EGILRGAATC FYAFVGFDCI ATTGEEAQNP QRSIPMGIVI SLSVCFLAYF
   301  AVSSALTLMM PYYQLQPESP LPEAFLYIGW APARYVVAVG SLCALSTSLL GSMFPMPRVI
   361  YAMAEDGLLF RVLARIHTGT RTPIIATVVS GIIAAFMAFL FKLTDLVDLM SIGTLLAYSL
   421  VSICVLILRY QPDQETKTGE EVELQEEAIT TESEKLTLWG LFFPLNSIPT PLSGQIVYVC
   481  SSLLAVLLTA LCLVLAQWSV PLLSGDLLWT AVVVLLLLLI IGIIVVIWRQ PQSSTPLHFK
   541  VPALPLLPLM SIFVNIYLMM QMTAGTWARF GVWMLIGFAI YFGYGIQHSL EEIKSNQPSR
   601  KSRAKTVDLD PGTLYVHSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC7A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 14
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

thymus: 18 nTPM
prostate: 5.4 nTPM
seminal vesicle: 5.1 nTPM
endometrium: 4.5 nTPM
cervix: 3.1 nTPM
hypothalamus: 3 nTPM

Single-cell type

medullary thymic epithelial cells: 19 nCPM
early spermatids: 8.3 nCPM
late primary spermatocytes: 7.5 nCPM
other brain neurons: 4.9 nCPM
epididymal basal cells: 4 nCPM
late spermatids: 3.1 nCPM

Immune cell

naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

thalamus: 12 nTPM
basal ganglia: 8.5 nTPM
hypothalamus: 7.6 nTPM
pons: 4.6 nTPM
midbrain: 4 nTPM
amygdala: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.18
gnomAD pLI: 1
gnomAD missense Z: 1.9
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

amino acid transport
L-arginine import across plasma membrane
transport across blood-brain barrier
L-lysine import across plasma membrane
L-ornithine import across plasma membrane

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC7A3 as an antibody target. Whether an autoantibody or antibody against SLC7A3 could matter depends on whether native SLC7A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC7A3 is annotated at the cell surface, where native SLC7A3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC7A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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