SLC7A2
Cationic amino acid transporter 2
Also known as: ATRC2, CAT-2, CTR2_HUMAN, HCAT2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P52569
- Gene
- SLC7A2
- Ensembl
- ENSG00000003989
- Chromosome
- 8
- Canonical length
- 658 aa
- Protein class
- Metabolic proteins, Predicted membrane proteins, Transporters
- Subcellular location
- Plasma membrane,Cell Junctions
OverviewNCBI Gene
The protein encoded by this gene is a cationic amino acid transporter and a member of the APC (amino acid-polyamine-organocation) family of transporters. The encoded membrane protein is responsible for the cellular uptake of arginine, lysine and ornithine. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Canonical amino-acid sequenceUniProt
658 residues, UniProt reviewed canonical sequence.
>P52569|SLC7A2
1 MIPCRAALTF ARCLIRRKIV TLDSLEDTKL CRCLSTMDLI ALGVGSTLGA GVYVLAGEVA
61 KADSGPSIVV SFLIAALASV MAGLCYAEFG ARVPKTGSAY LYTYVTVGEL WAFITGWNLI
121 LSYVIGTSSV ARAWSGTFDE LLSKQIGQFL RTYFRMNYTG LAEYPDFFAV CLILLLAGLL
181 SFGVKESAWV NKVFTAVNIL VLLFVMVAGF VKGNVANWKI SEEFLKNISA SAREPPSENG
241 TSIYGAGGFM PYGFTGTLAG AATCFYAFVG FDCIATTGEE VRNPQKAIPI GIVTSLLVCF
301 MAYFGVSAAL TLMMPYYLLD EKSPLPVAFE YVGWGPAKYV VAAGSLCALS TSLLGSIFPM
361 PRVIYAMAED GLLFKCLAQI NSKTKTPIIA TLSSGAVAAL MAFLFDLKAL VDMMSIGTLM
421 AYSLVAACVL ILRYQPGLSY DQPKCSPEKD GLGSSPRVTS KSESQVTMLQ RQGFSMRTLF
481 CPSLLPTQQS ASLVSFLVGF LAFLVLGLSV LTTYGVHAIT RLEAWSLALL ALFLVLFVAI
541 VLTIWRQPQN QQKVAFMVPF LPFLPAFSIL VNIYLMVQLS ADTWVRFSIW MAIGFLIYFS
601 YGIRHSLEGH LRDENNEEDA YPDNVHAAAE EKSAIQANDH HPRNLSSPFI FHEKTSEFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SLC7A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 14
- Mean surface accessibility (rSASA)
- 0.27
- Highest tissue expression
- 211 nTPM
Expression across tissuesHPA
Tissue
- parathyroid gland: 211 nTPM
- liver: 165 nTPM
- skeletal muscle: 108 nTPM
- ovary: 79 nTPM
- pancreas: 78 nTPM
- tongue: 43 nTPM
Single-cell type
- myonuclei: 662 nCPM
- pancreatic islet cells: 621 nCPM
- pancreatic acinar cells: 609 nCPM
- endometrial glandular cells: 574 nCPM
- epicardial cells: 482 nCPM
- hepatocytes: 380 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- choroid plexus: 35 nTPM
- white matter: 34 nTPM
- medulla oblongata: 31 nTPM
- spinal cord: 28 nTPM
- pons: 23 nTPM
- hippocampal formation: 21 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.01
- gnomAD pLI
- 0
- gnomAD missense Z
- -1.41
- DepMap mean gene effect
- 0.16
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- amino acid import across plasma membrane
- amino acid transport
- L-alpha-amino acid transmembrane transport
- L-amino acid transport
- L-arginine import across plasma membrane
- L-arginine transmembrane transport
- L-ornithine transmembrane transport
- transport across blood-brain barrier
Molecular functions
- amino acid transmembrane transporter activity
- basic amino acid transmembrane transporter activity
- L-amino acid transmembrane transporter activity
- L-arginine transmembrane transporter activity
- L-lysine transmembrane transporter activity
- L-ornithine transmembrane transporter activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SLC7A2 as an antibody target. Whether an autoantibody or antibody against SLC7A2 could matter depends on whether native SLC7A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SLC7A2 is annotated at the cell surface, where native SLC7A2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label SLC7A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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