Seroatlas · Human Serome Atlas

SLC7A13

Solute carrier family 7 member 13

Also known as: AGT-1, S7A13_HUMAN, XAT2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TCU3
Gene: SLC7A13
Ensembl: ENSG00000164893
Chromosome: 8
Canonical length: 470 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to be located in plasma membrane. Predicted to be active in apical plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

470 residues, UniProt reviewed canonical sequence.

>Q8TCU3|SLC7A13
     1  MDRGEKIQLK RVFGYWWGTS FLLINIIGAG IFVSPKGVLA YSCMNVGVSL CVWAGCAILA
    61  MTSTLCSAEI SISFPCSGAQ YYFLKRYFGS TVAFLNLWTS LFLGSGVVAG QALLLAEYSI
   121  QPFFPSCSVP KLPKKCLALA MLWIVGILTS RGVKEVTWLQ IASSVLKVSI LSFISLTGVV
   181  FLIRGKKENV ERFQNAFDAE LPDISHLIQA IFQGYFAYSG GACFTLIAGE LKKPRTTIPK
   241  CIFTALPLVT VVYLLVNISY LTVLTPREIL SSDAVAITWA DRAFPSLAWI MPFAISTSLF
   301  SNLLISIFKS SRPIYLASQE GQLPLLFNTL NSHSSPFTAV LLLVTLGSLA IILTSLIDLI
   361  NYIFFTGSLW SILLMIGILR RRYQEPNLSI PYKVFLSFPL ATIVIDVGLV VIPLVKSPNV
   421  HYVYVLLLVL SGLLFYIPLI HFKIRLAWFE KMTCYLQLLF NICLPDVSEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC7A13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

kidney: 39 nTPM
breast: 0.1 nTPM
skeletal muscle: 0.1 nTPM
skin: 0.1 nTPM
testis: 0.1 nTPM
adipose tissue: 0 nTPM

Single-cell type

proximal tubule cells: 23 nCPM
prostatic glandular cells: 4.4 nCPM
podocytes: 3.9 nCPM
leydig cells: 3.7 nCPM
cone photoreceptor cells: 2.1 nCPM
early spermatids: 2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 0.5 nTPM
basal ganglia: 0.3 nTPM
cerebral cortex: 0.3 nTPM
hypothalamus: 0.3 nTPM
medulla oblongata: 0.3 nTPM
midbrain: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.73
gnomAD pLI: 0
gnomAD missense Z: -0.9
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

apical plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC7A13 as an antibody target. Whether an autoantibody or antibody against SLC7A13 could matter depends on whether native SLC7A13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC7A13 is annotated at the cell surface, where native SLC7A13 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC7A13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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