Seroatlas · Human Serome Atlas

SLC7A10

Asc-type amino acid transporter 1

Also known as: AAA1_HUMAN, asc-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NS82
Gene
SLC7A10
Ensembl
ENSG00000130876
Chromosome
19
Canonical length
523 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

SLC7A10, in association with 4F2HC (SLC3A2; MIM 158070), mediates high-affinity transport of D-serine and several other neutral amino acids (Nakauchi et al., 2000 [PubMed 10863037]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

523 residues, UniProt reviewed canonical sequence.

>Q9NS82|SLC7A10
     1  MAGHTQQPSG RGNPRPAPSP SPVPGTVPGA SERVALKKEI GLLSACTIII GNIIGSGIFI
    61  SPKGVLEHSG SVGLALFVWV LGGGVTALGS LCYAELGVAI PKSGGDYAYV TEIFGGLAGF
   121  LLLWSAVLIM YPTSLAVISM TFSNYVLQPV FPNCIPPTTA SRVLSMACLM LLTWVNSSSV
   181  RWATRIQDMF TGGKLLALSL IIGVGLLQIF QGHFEELRPS NAFAFWMTPS VGHLALAFLQ
   241  GSFAFSGWNF LNYVTEEMVD ARKNLPRAIF ISIPLVTFVY TFTNIAYFTA MSPQELLSSN
   301  AVAVTFGEKL LGYFSWVMPV SVALSTFGGI NGYLFTYSRL CFSGAREGHL PSLLAMIHVR
   361  HCTPIPALLV CCGATAVIML VGDTYTLINY VSFINYLCYG VTILGLLLLR WRRPALHRPI
   421  KVNLLIPVAY LVFWAFLLVF SFISEPMVCG VGVIIILTGV PIFFLGVFWR SKPKCVHRLT
   481  ESMTHWGQEL CFVVYPQDAP EEEENGPCPP SLLPATDKPS KPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC7A10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
9
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
30 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 30 nTPM
  • basal ganglia: 20 nTPM
  • amygdala: 14 nTPM
  • cerebral cortex: 13 nTPM
  • breast: 13 nTPM
  • midbrain: 11 nTPM

Single-cell type

  • astrocytes: 59 nCPM
  • adipocytes: 47 nCPM
  • retinal pigment epithelial cells: 43 nCPM
  • bergmann glia: 29 nCPM
  • oligodendrocyte progenitor cells: 20 nCPM
  • undifferentiated spermatogonia: 9.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • thalamus: 22 nTPM
  • midbrain: 21 nTPM
  • cerebellum: 16 nTPM
  • basal ganglia: 15 nTPM
  • hypothalamus: 14 nTPM
  • pons: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.77
gnomAD pLI
0
gnomAD missense Z
1.11
DepMap mean gene effect
-0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC7A10 as an antibody target. Whether an autoantibody or antibody against SLC7A10 could matter depends on whether native SLC7A10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC7A10 is annotated at the cell surface, where native SLC7A10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC7A10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC7A10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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