Seroatlas · Human Serome Atlas

SLC6A7

Sodium-dependent proline transporter

Also known as: PROT, SC6A7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99884
Gene: SLC6A7
Ensembl: ENSG00000011083
Chromosome: 5
Canonical length: 636 aa
Protein class: Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

This gene is a member of the gamma-aminobutyric acid (GABA) neurotransmitter gene family and encodes a high-affinity mammalian brain L-proline transporter protein. This transporter protein differs from other sodium-dependent plasma membrane carriers by its pharmacological specificity, kinetic properties, and ionic requirements. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

636 residues, UniProt reviewed canonical sequence.

>Q99884|SLC6A7
     1  MKKLQGAHLR KPVTPDLLMT PSDQGDVDLD VDFAAHRGNW TGKLDFLLSC IGYCVGLGNV
    61  WRFPYRAYTN GGGAFLVPYF LMLAICGIPL FFLELSLGQF SSLGPLAVWK ISPLFKGAGA
   121  AMLLIVGLVA IYYNMIIAYV LFYLFASLTS DLPWEHCGNW WNTELCLEHR VSKDGNGALP
   181  LNLTCTVSPS EEYWSRYVLH IQGSQGIGSP GEIRWNLCLC LLLAWVIVFL CILKGVKSSG
   241  KVVYFTATFP YLILLMLLVR GVTLPGAWKG IQFYLTPQFH HLLSSKVWIE AALQIFYSLG
   301  VGFGGLLTFA SYNTFHQNIY RDTFIVTLGN AITSILAGFA IFSVLGYMSQ ELGVPVDQVA
   361  KAGPGLAFVV YPQAMTMLPL SPFWSFLFFF MLLTLGLDSQ FAFLETIVTA VTDEFPYYLR
   421  PKKAVFSGLI CVAMYLMGLI LTTDGGMYWL VLLDDYSASF GLMVVVITTC LAVTRVYGIQ
   481  RFCRDIHMML GFKPGLYFRA CWLFLSPATL LALMVYSIVK YQPSEYGSYR FPPWAELLGI
   541  LMGLLSCLMI PAGMLVAVLR EEGSLWERLQ QASRPAMDWG PSLEENRTGM YVATLAGSQS
   601  PKPLMVHMRK YGGITSFENT AIEVDREIAE EEESMM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC6A7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 68 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 68 nTPM
cerebral cortex: 30 nTPM
hippocampal formation: 6.6 nTPM
hypothalamus: 5.9 nTPM
colon: 5.4 nTPM
amygdala: 4.1 nTPM

Single-cell type

brain excitatory neurons: 52 nCPM
colonocytes: 32 nCPM
goblet cells: 27 nCPM
thymic myoid cells: 22 nCPM
enteric stem cells: 22 nCPM
cardiomyocytes: 21 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 53 nTPM
cerebellum: 37 nTPM
basal ganglia: 29 nTPM
thalamus: 28 nTPM
white matter: 27 nTPM
hippocampal formation: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.88
gnomAD pLI: 0
gnomAD missense Z: 0.52
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC6A7 as an antibody target. Whether an autoantibody or antibody against SLC6A7 could matter depends on whether native SLC6A7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC6A7 is annotated at the cell surface, where native SLC6A7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC6A7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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