Seroatlas · Human Serome Atlas

SLC6A6

Sodium- and chloride-dependent taurine transporter

Also known as: SC6A6_HUMAN, TAUT

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P31641
Gene
SLC6A6
Ensembl
ENSG00000131389
Chromosome
3
Canonical length
620 aa
Protein class
Disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Cell Junctions,Cytosol

OverviewNCBI Gene

This gene encodes a multi-pass membrane protein that is a member of a family of sodium and chloride-ion dependent transporters. The encoded protein transports taurine and beta-alanine. There is a pseudogene for this gene on chromosome 21. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Canonical amino-acid sequenceUniProt

620 residues, UniProt reviewed canonical sequence.

>P31641|SLC6A6
     1  MATKEKLQCL KDFHKDILKP SPGKSPGTRP EDEAEGKPPQ REKWSSKIDF VLSVAGGFVG
    61  LGNVWRFPYL CYKNGGGAFL IPYFIFLFGS GLPVFFLEII IGQYTSEGGI TCWEKICPLF
   121  SGIGYASVVI VSLLNVYYIV ILAWATYYLF QSFQKELPWA HCNHSWNTPH CMEDTMRKNK
   181  SVWITISSTN FTSPVIEFWE RNVLSLSPGI DHPGSLKWDL ALCLLLVWLV CFFCIWKGVR
   241  STGKVVYFTA TFPFAMLLVL LVRGLTLPGA GAGIKFYLYP DITRLEDPQV WIDAGTQIFF
   301  SYAICLGAMT SLGSYNKYKY NSYRDCMLLG CLNSGTSFVS GFAIFSILGF MAQEQGVDIA
   361  DVAESGPGLA FIAYPKAVTM MPLPTFWSIL FFIMLLLLGL DSQFVEVEGQ ITSLVDLYPS
   421  FLRKGYRREI FIAFVCSISY LLGLTMVTEG GMYVFQLFDY YAASGVCLLW VAFFECFVIA
   481  WIYGGDNLYD GIEDMIGYRP GPWMKYSWAV ITPVLCVGCF IFSLVKYVPL TYNKTYVYPN
   541  WAIGLGWSLA LSSMLCVPLV IVIRLCQTEG PFLVRVKYLL TPREPNRWAV EREGATPYNS
   601  RTVMNGALVK PTHIIVETMM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC6A6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
134 nTPM

Expression across tissuesHPA

Tissue

  • retina: 134 nTPM
  • bone marrow: 60 nTPM
  • ovary: 32 nTPM
  • skeletal muscle: 30 nTPM
  • heart muscle: 26 nTPM
  • adrenal gland: 26 nTPM

Single-cell type

  • rod photoreceptor cells: 1,194 nCPM
  • cone photoreceptor cells: 1,099 nCPM
  • neutrophils: 1,044 nCPM
  • endometrial glandular cells: 344 nCPM
  • conjunctival goblet cells: 338 nCPM
  • retinal pigment epithelial cells: 290 nCPM

Immune cell

  • neutrophil: 57 nTPM
  • non-classical monocyte: 11 nTPM
  • T-reg: 8.7 nTPM
  • classical monocyte: 8.2 nTPM
  • eosinophil: 8 nTPM
  • intermediate monocyte: 6.5 nTPM

Brain region

  • thalamus: 46 nTPM
  • medulla oblongata: 40 nTPM
  • midbrain: 33 nTPM
  • basal ganglia: 32 nTPM
  • cerebral cortex: 32 nTPM
  • pons: 31 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC6A6.

Disease | AllUniProt

Conditions SLC6A6 is implicated in, by any mechanism.

  • Hypotaurinemic retinal degeneration and cardiomyopathy (HTRDC) MIM:145350

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 98 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Retinal degeneration
  • Hypotaurinemic retinal degeneration and cardiomyopathy
  • Retinal dystrophy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.99
gnomAD missense Z
3.39
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC6A6 as an antibody target. Whether an autoantibody or antibody against SLC6A6 could matter depends on whether native SLC6A6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC6A6 is annotated at the cell surface, where native SLC6A6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC6A6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC6A6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...