Seroatlas · Human Serome Atlas

SLC6A16

Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5

Also known as: NTT5, S6A16_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9GZN6
Gene: SLC6A16
Ensembl: ENSG00000063127
Chromosome: 19
Canonical length: 736 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus

OverviewNCBI Gene

SLC6A16 shows structural characteristics of an Na(+)- and Cl(-)-dependent neurotransmitter transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-glycosylation sites.[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

736 residues, UniProt reviewed canonical sequence.

>Q9GZN6|SLC6A16
     1  MKTEAQPSTS LLANTSWTGT VISDSVPGSQ TWEDKGSLTR SATSWTSEAQ VSAARVAEAQ
    61  ARTSQPKQIS VLEALTASAL NQKPTHEKVQ MTEKKESEVL LARPFWSSKT EYILAQVGFS
   121  MKPSCLWRFA YLWLNSGGCS FAAIYIFMLF LVGVPLLFLE MAAGQSMRQG GMGVWKIIAP
   181  WIGGVGYSSF MVCFILGLYF NVVNSWIIFY MSQSFQFPVP WEKCPLTMNS SGFDPECERT
   241  TPSIYFWYQQ ALKASDRIED GGSPVYSLVL PFFLCWCLVG AFMINGLKST GKVIYVLVLL
   301  PCFIIVGFFI RTLLLEGAKF GLQQLVVAKI SDVYNMSVWS LAGGQVLSNT GIGLGSVASL
   361  ASYMPQSNNC LSDAFLVSVI NLLTLLVFTS FNFCVLGFWA TVITHRCCER NAEILLKLIN
   421  LGKLPPDAKP PVNLLYNPTS IYNAWLSGLP QHIKSMVLRE VTECNIETQF LKASEGPKFA
   481  FLSFVEAMSF LPPSVFWSFI FFLMLLAMGL SSAIGIMQGI ITPLQDTFSF FRKHTKLLIV
   541  GVFLLMFVCG LFFTRPSGSY FIRLLSDYWI VFPIIVVVVF ETMAVSWAYG ARRFLADLTI
   601  LLGHPISPIF GWLWPHLCPV VLLIIFVTMM VHLCMKPITY MSWDSSTSKE VLRPYPPWAL
   661  LLMITLFAIV ILPIPAYFVY CRIHRIPFRP KSGDGPMTAS TSLPLSHQLT PSKEVQKEEI
   721  LQVDETKYPS TCNVTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC6A16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 88 nTPM

Expression across tissuesHPA

Tissue

testis: 88 nTPM
choroid plexus: 15 nTPM
liver: 9.4 nTPM
blood vessel: 9.2 nTPM
kidney: 7.1 nTPM
ovary: 6.8 nTPM

Single-cell type

late primary spermatocytes: 252 nCPM
early primary spermatocytes: 180 nCPM
ependymal cells: 128 nCPM
choroid plexus epithelial cells: 127 nCPM
early spermatids: 102 nCPM
respiratory ciliated cells: 72 nCPM

Immune cell

memory B-cell: 4.5 nTPM
eosinophil: 2.6 nTPM
naive B-cell: 2.2 nTPM
non-classical monocyte: 2.1 nTPM
neutrophil: 1.8 nTPM
NK-cell: 1.8 nTPM

Brain region

choroid plexus: 38 nTPM
medulla oblongata: 12 nTPM
midbrain: 12 nTPM
pons: 11 nTPM
spinal cord: 8 nTPM
amygdala: 7.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: 0.99
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC6A16 as an antibody target. Whether an autoantibody or antibody against SLC6A16 could matter depends on whether native SLC6A16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC6A16 is annotated at the cell surface, where native SLC6A16 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC6A16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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