Seroatlas · Human Serome Atlas

SLC6A14

Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

Also known as: S6A14_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UN76
Gene
SLC6A14
Ensembl
ENSG00000268104
Chromosome
X
Canonical length
642 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Vesicles,Plasma membrane,Primary cilium,Primary cilium tip,Mitochondria

OverviewNCBI Gene

This gene encodes a member of the solute carrier family 6. Members of this family are sodium and chloride dependent neurotransmitter transporters. The encoded protein transports both neutral and cationic amino acids. This protein may also function as a beta-alanine carrier. Mutations in this gene may be associated with X-linked obesity. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

642 residues, UniProt reviewed canonical sequence.

>Q9UN76|SLC6A14
     1  MDKLKCPSFF KCREKEKVSA SSENFHVGEN DENQDRGNWS KKSDYLLSMI GYAVGLGNVW
    61  RFPYLTYSNG GGAFLIPYAI MLALAGLPLF FLECSLGQFA SLGPVSVWRI LPLFQGVGIT
   121  MVLISIFVTI YYNVIIAYSL YYMFASFQSE LPWKNCSSWS DKNCSRSPIV THCNVSTVNK
   181  GIQEIIQMNK SWVDINNFTC INGSEIYQPG QLPSEQYWNK VALQRSSGMN ETGVIVWYLA
   241  LCLLLAWLIV GAALFKGIKS SGKVVYFTAL FPYVVLLILL VRGATLEGAS KGISYYIGAQ
   301  SNFTKLKEAE VWKDAATQIF YSLSVAWGGL VALSSYNKFK NNCFSDAIVV CLTNCLTSVF
   361  AGFAIFSILG HMAHISGKEV SQVVKSGFDL AFIAYPEALA QLPGGPFWSI LFFFMLLTLG
   421  LDSQFASIET ITTTIQDLFP KVMKKMRVPI TLGCCLVLFL LGLVCVTQAG IYWVHLIDHF
   481  CAGWGILIAA ILELVGIIWI YGGNRFIEDT EMMIGAKRWI FWLWWRACWF VITPILLIAI
   541  FIWSLVQFHR PNYGAIPYPD WGVALGWCMI VFCIIWIPIM AIIKIIQAKG NIFQRLISCC
   601  RPASNWGPYL EQHRGERYKD MVDPKKEADH EIPTVSGSRK PE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC6A14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 20 nTPM
  • lung: 15 nTPM
  • breast: 7.2 nTPM
  • cervix: 6.5 nTPM
  • vagina: 4.8 nTPM
  • stomach: 3.6 nTPM

Single-cell type

  • alveolar cells type 2: 470 nCPM
  • salivary acinar cells: 320 nCPM
  • respiratory secretory cells: 228 nCPM
  • transitional alveolar cells: 159 nCPM
  • respiratory deuterosomal cells: 137 nCPM
  • respiratory basal cells: 115 nCPM

Immune cell

  • basophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 1.3 nTPM
  • cerebral cortex: 0.9 nTPM
  • white matter: 0.9 nTPM
  • amygdala: 0.8 nTPM
  • hippocampal formation: 0.8 nTPM
  • medulla oblongata: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.43
gnomAD pLI
0.56
gnomAD missense Z
1.28
DepMap mean gene effect
0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC6A14 as an antibody target. Whether an autoantibody or antibody against SLC6A14 could matter depends on whether native SLC6A14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC6A14 is annotated at the cell surface, where native SLC6A14 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC6A14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC6A14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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