Seroatlas · Human Serome Atlas

SLC6A13

Sodium- and chloride-dependent GABA transporter 2

Also known as: GAT2, S6A13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NSD5
Gene
SLC6A13
Ensembl
ENSG00000010379
Chromosome
12
Canonical length
602 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Nucleoli,Mitochondria,Cytosol

OverviewNCBI Gene

Enables gamma-aminobutyric acid:sodium:chloride symporter activity. Involved in amino acid import across plasma membrane and monocarboxylic acid transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

602 residues, UniProt reviewed canonical sequence.

>Q9NSD5|SLC6A13
     1  MDSRVSGTTS NGETKPVYPV MEKKEEDGTL ERGHWNNKME FVLSVAGEII GLGNVWRFPY
    61  LCYKNGGGAF FIPYLVFLFT CGIPVFLLET ALGQYTSQGG VTAWRKICPI FEGIGYASQM
   121  IVILLNVYYI IVLAWALFYL FSSFTIDLPW GGCYHEWNTE HCMEFQKTNG SLNGTSENAT
   181  SPVIEFWERR VLKISDGIQH LGALRWELAL CLLLAWVICY FCIWKGVKST GKVVYFTATF
   241  PYLMLVVLLI RGVTLPGAAQ GIQFYLYPNL TRLWDPQVWM DAGTQIFFSF AICLGCLTAL
   301  GSYNKYHNNC YRDCIALCFL NSGTSFVAGF AIFSILGFMS QEQGVPISEV AESGPGLAFI
   361  AYPRAVVMLP FSPLWACCFF FMVVLLGLDS QFVCVESLVT ALVDMYPHVF RKKNRREVLI
   421  LGVSVVSFLV GLIMLTEGGM YVFQLFDYYA ASGMCLLFVA IFESLCVAWV YGAKRFYDNI
   481  EDMIGYRPWP LIKYCWLFLT PAVCTATFLF SLIKYTPLTY NKKYTYPWWG DALGWLLALS
   541  SMVCIPAWSL YRLGTLKGPF RERIRQLMCP AEDLPQRNPA GPSAPATPRT SLLRLTELES
   601  HC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC6A13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
143 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 143 nTPM
  • liver: 37 nTPM
  • choroid plexus: 17 nTPM
  • basal ganglia: 14 nTPM
  • cerebral cortex: 12 nTPM
  • midbrain: 8.6 nTPM

Single-cell type

  • retinal pigment epithelial cells: 733 nCPM
  • proximal tubule cells: 422 nCPM
  • epididymal efferent duct absorptive cells: 40 nCPM
  • hepatocytes: 38 nCPM
  • pericytes: 27 nCPM
  • renal connecting tubule cells: 19 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 19 nTPM
  • cerebral cortex: 15 nTPM
  • choroid plexus: 14 nTPM
  • thalamus: 13 nTPM
  • amygdala: 12 nTPM
  • midbrain: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.98
gnomAD pLI
0
gnomAD missense Z
0.02
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC6A13 as an antibody target. Whether an autoantibody or antibody against SLC6A13 could matter depends on whether native SLC6A13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC6A13 is annotated at the cell surface, where native SLC6A13 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC6A13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC6A13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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