Seroatlas · Human Serome Atlas

SLC66A3

Solute carrier family 66 member 3

Also known as: C2orf22, MGC33602, PQLC3, S66A3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N755
Gene: SLC66A3
Ensembl: ENSG00000162976
Chromosome: 2
Canonical length: 202 aa
Protein class: Predicted membrane proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

202 residues, UniProt reviewed canonical sequence.

>Q8N755|SLC66A3
     1  MEAALLGLCN WSTLGVCAAL KLPQISAVLA ARSARGLSLP SLLLELAGFL VFLRYQCYYG
    61  YPPLTYLEYP ILIAQDVILL LCIFHFNGNV KQATPYIAVL VSSWFILALQ KWIIDLAMNL
   121  CTFISAASKF AQLQCLWKTR DSGTVSALTW SLSSYTCATR IITTLMTTND FTILLRFVIM
   181  LALNIWVTVT VLRYRKTAIK AE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC66A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

epididymis: 45 nTPM
spleen: 38 nTPM
cervix: 36 nTPM
ovary: 33 nTPM
adipose tissue: 31 nTPM
pancreas: 28 nTPM

Single-cell type

kupffer cells: 129 nCPM
extravillous trophoblasts: 117 nCPM
oocytes: 83 nCPM
decidual stromal cells: 82 nCPM
epididymal clear cells: 74 nCPM
hepatic stellate cells: 71 nCPM

Immune cell

non-classical monocyte: 209 nTPM
intermediate monocyte: 195 nTPM
total PBMC: 166 nTPM
classical monocyte: 154 nTPM
myeloid DC: 154 nTPM
eosinophil: 151 nTPM

Brain region

choroid plexus: 23 nTPM
white matter: 17 nTPM
medulla oblongata: 13 nTPM
spinal cord: 12 nTPM
pons: 10 nTPM
thalamus: 9.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.82
gnomAD pLI: 0
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC66A3 as an antibody target. Whether an autoantibody or antibody against SLC66A3 could matter depends on whether native SLC66A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC66A3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC66A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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