Seroatlas · Human Serome Atlas

SLC66A2

Solute carrier family 66 member 2

Also known as: FLJ22378, PQLC1, S66A2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N2U9
Gene: SLC66A2
Ensembl: ENSG00000122490
Chromosome: 18
Canonical length: 271 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be involved in phospholipid translocation and retrograde transport, endosome to Golgi. Predicted to be located in cytosol and membrane. Predicted to be active in endosome and trans-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

271 residues, UniProt reviewed canonical sequence.

>Q8N2U9|SLC66A2
     1  MEAEGLDWLL VPLHQLVSWG AAAAMVFGGV VPYVPQYRDI RRTQNADGFS TYVCLVLLVA
    61  NILRILFWFG RRFESPLLWQ SAIMILTMLL MLKLCTEVRV ANELNARRRS FTAADSKDEE
   121  VKVAPRRSFL DFDPHHFWQW SSFSDYVQCV LAFTGVAGYI TYLSIDSALF VETLGFLAVL
   181  TEAMLGVPQL YRNHRHQSTE GMSIKMVLMW TSGDAFKTAY FLLKGAPLQF SVCGLLQVLV
   241  DLAILGQAYA FARHPQKPAP HAVHPTGTKA L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC66A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 179 nTPM

Expression across tissuesHPA

Tissue

liver: 179 nTPM
skeletal muscle: 79 nTPM
testis: 74 nTPM
thyroid gland: 65 nTPM
hippocampal formation: 58 nTPM
cerebral cortex: 57 nTPM

Single-cell type

late spermatids: 303 nCPM
neutrophils: 293 nCPM
hepatocytes: 248 nCPM
proximal tubule cells: 224 nCPM
thymic myoid cells: 189 nCPM
esophageal apical cells: 172 nCPM

Immune cell

plasmacytoid DC: 3.4 nTPM
eosinophil: 2 nTPM
myeloid DC: 1.9 nTPM
classical monocyte: 1.7 nTPM
intermediate monocyte: 1.7 nTPM
non-classical monocyte: 1.6 nTPM

Brain region

hippocampal formation: 58 nTPM
cerebral cortex: 56 nTPM
thalamus: 53 nTPM
medulla oblongata: 53 nTPM
choroid plexus: 50 nTPM
amygdala: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.91
gnomAD pLI: 0.01
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

PQ-loop repeat
PQ loop repeat
Solute Carrier Family 66 (SLC66) and Scramblase ANY1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC66A2 as an antibody target. Whether an autoantibody or antibody against SLC66A2 could matter depends on whether native SLC66A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC66A2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC66A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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