Seroatlas · Human Serome Atlas

SLC66A1LP

Putative uncharacterized protein SLC66A1LP

Also known as: S66AL_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A1A4F0
Gene: SLC66A1LP
Canonical length: 135 aa

OverviewNCBI Gene

No narrative summary is available for SLC66A1LP in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

135 residues, UniProt reviewed canonical sequence.

>A1A4F0|SLC66A1LP
     1  MKVVGNYRVN TANSSTDTSG EHLTCLRSQL FVAYRNGRVD EAVSLGFLDC WIGGDLTNFK
    61  GCYLTNQLPI QIFTAIFDMN TDVIILSQFM YYRLKNQKKK MIFQPQLFKD SITREKVRLS
   121  LWGVLCPVYI PYSFR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC66A1LP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

L-lysine transmembrane transporter activity

Cellular components

lysosomal membrane

Protein domainsUniProt · Pfam · InterPro

Lysosomal/Vacuolar Amino Acid Transporter 1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC66A1LP as an antibody target. Whether an autoantibody or antibody against SLC66A1LP could matter depends on whether native SLC66A1LP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC66A1LP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC66A1LP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...