Seroatlas · Human Serome Atlas

SLC66A1

Lysosomal amino acid transporter 1 homolog

Also known as: FLJ20320, LAAT-1, LAAT1, LAAT1_HUMAN, PQLC2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZP29
Gene: SLC66A1
Ensembl: ENSG00000040487
Chromosome: 1
Canonical length: 291 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Vesicles

OverviewNCBI Gene

Enables L-arginine transmembrane transporter activity; L-histidine transmembrane transporter activity; and L-lysine transmembrane transporter activity. Involved in L-amino acid transport and intracellular amino acid homeostasis. Located in lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

291 residues, UniProt reviewed canonical sequence.

>Q6ZP29|SLC66A1
     1  MVWKKLGSRN FSSCPSGSIQ WIWDVLGECA QDGWDEASVG LGLISILCFA ASTFPQFIKA
    61  YKTGNMDQAL SLWFLLGWIG GDSCNLIGSF LADQLPLQTY TAVYYVLADL VMLTLYFYYK
   121  FRTRPSLLSA PINSVLLFLM GMACATPLLS AAGPVAAPRE AFRGRALLSV ESGSKPFTRQ
   181  EVIGFVIGSI SSVLYLLSRL PQIRTNFLRK STQGISYSLF ALVMLGNTLY GLSVLLKNPE
   241  EGQSEGSYLL HHLPWLVGSL GVLLLDTIIS IQFLVYRRST AASELEPLLP S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC66A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 31 nTPM
liver: 26 nTPM
adrenal gland: 24 nTPM
pituitary gland: 23 nTPM
testis: 18 nTPM
pancreas: 17 nTPM

Single-cell type

syncytiotrophoblasts: 83 nCPM
hofbauer cells: 61 nCPM
cytotrophoblasts: 31 nCPM
migrating cytotrophoblasts: 24 nCPM
extravillous trophoblasts: 20 nCPM
megakaryocytes: 19 nCPM

Immune cell

plasmacytoid DC: 21 nTPM
non-classical monocyte: 14 nTPM
myeloid DC: 14 nTPM
classical monocyte: 11 nTPM
eosinophil: 10 nTPM
intermediate monocyte: 9.1 nTPM

Brain region

cerebellum: 32 nTPM
cerebral cortex: 28 nTPM
medulla oblongata: 28 nTPM
pons: 26 nTPM
white matter: 26 nTPM
thalamus: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC66A1 as an antibody target. Whether an autoantibody or antibody against SLC66A1 could matter depends on whether native SLC66A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC66A1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC66A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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