Seroatlas · Human Serome Atlas

SLC5A9

Sodium/glucose cotransporter 4

Also known as: SC5A9_HUMAN, SGLT4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q2M3M2
Gene
SLC5A9
Ensembl
ENSG00000117834
Chromosome
1
Canonical length
681 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Actin filaments,Cytosol

OverviewNCBI Gene

Predicted to enable D-glucose:sodium symporter activity. Predicted to be involved in hexose transmembrane transport. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

681 residues, UniProt reviewed canonical sequence.

>Q2M3M2|SLC5A9
     1  MSKELAAMGP GASGDGVRTE TAPHIALDSR VGLHAYDISV VVIYFVFVIA VGIWSSIRAS
    61  RGTIGGYFLA GRSMSWWPIG ASLMSSNVGS GLFIGLAGTG AAGGLAVGGF EWNATWLLLA
   121  LGWVFVPVYI AAGVVTMPQY LKKRFGGQRI QVYMSVLSLI LYIFTKISTD IFSGALFIQM
   181  ALGWNLYLST GILLVVTAVY TIAGGLMAVI YTDALQTVIM VGGALVLMFL GFQDVGWYPG
   241  LEQRYRQAIP NVTVPNTTCH LPRPDAFHIL RDPVSGDIPW PGLIFGLTVL ATWCWCTDQV
   301  IVQRSLSAKS LSHAKGGSVL GGYLKILPMF FIVMPGMISR ALFPDEVGCV DPDVCQRICG
   361  ARVGCSNIAY PKLVMALMPV GLRGLMIAVI MAALMSSLTS IFNSSSTLFT IDVWQRFRRK
   421  STEQELMVVG RVFVVFLVVI SILWIPIIQS SNSGQLFDYI QAVTSYLAPP ITALFLLAIF
   481  CKRVTEPGAF WGLVFGLGVG LLRMILEFSY PAPACGEVDR RPAVLKDFHY LYFAILLCGL
   541  TAIVIVIVSL CTTPIPEEQL TRLTWWTRNC PLSELEKEAH ESTPEISERP AGECPAGGGA
   601  AENSSLGQEQ PEAPSRSWGK LLWSWFCGLS GTPEQALSPA EKAALEQKLT SIEEEPLWRH
   661  VCNINAVLLL AINIFLWGYF A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC5A9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
14
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
41 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 41 nTPM
  • small intestine: 40 nTPM
  • liver: 7.3 nTPM
  • kidney: 3.8 nTPM
  • pancreas: 3.7 nTPM
  • lung: 2.8 nTPM

Single-cell type

  • enterocytes: 96 nCPM
  • epicardial cells: 84 nCPM
  • proximal tubule cells: 46 nCPM
  • fibro-adipogenic progenitors: 27 nCPM
  • late spermatids: 19 nCPM
  • epididymal efferent duct absorptive cells: 18 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 1 nTPM
  • midbrain: 0.8 nTPM
  • basal ganglia: 0.7 nTPM
  • cerebral cortex: 0.7 nTPM
  • choroid plexus: 0.7 nTPM
  • medulla oblongata: 0.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC5A9.

Disease | ImmuneIEDB

Conditions an epitope on SLC5A9 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.36
gnomAD pLI
0
gnomAD missense Z
0.8
DepMap mean gene effect
-0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC5A9 as an antibody target. Whether an autoantibody or antibody against SLC5A9 could matter depends on whether native SLC5A9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC5A9 is annotated at the cell surface, where native SLC5A9 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC5A9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC5A9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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