Seroatlas · Human Serome Atlas

SLC5A8

Sodium-coupled monocarboxylate transporter 1

Also known as: AIT, SC5A8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N695
Gene
SLC5A8
Ensembl
ENSG00000256870
Chromosome
12
Canonical length
610 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

SLC5A8 has been shown to transport iodide by a passive mechanism (Rodriguez et al., 2002 [PubMed 12107270]) and monocarboxylates and short-chain fatty acids by a sodium-coupled mechanism (Gopal et al., 2004 [PubMed 15322102]). In kidney, SLC5A8 functions as a high-affinity sodium-coupled lactate transporter involved in reabsorption of lactate and maintenance of blood lactate levels (Thangaraju et al., 2006 [PubMed 16873376]).[supplied by OMIM, Dec 2008]

Canonical amino-acid sequenceUniProt

610 residues, UniProt reviewed canonical sequence.

>Q8N695|SLC5A8
     1  MDTPRGIGTF VVWDYVVFAG MLVISAAIGI YYAFAGGGQQ TSKDFLMGGR RMTAVPVALS
    61  LTASFMSAVT VLGTPSEVYR FGAIFSIFAF TYFFVVVISA EVFLPVFYKL GITSTYEYLE
   121  LRFNKCVRLC GTVLFIVQTI LYTGIVIYAP ALALNQVTGF DLWGAVVATG VVCTFYCTLG
   181  GLKAVIWTDV FQVGIMVAGF ASVIIQAVVM QGGISTILND AYDGGRLNFW NFNPNPLQRH
   241  TFWTIIIGGT FTWTSIYGVN QSQVQRYISC KSRFQAKLSL YINLVGLWAI LTCSVFCGLA
   301  LYSRYHDCDP WTAKKVSAPD QLMPYLVLDI LQDYPGLPGL FVACAYSGTL STVSSSINAL
   361  AAVTVEDLIK PYFRSLSERS LSWISQGMSV VYGALCIGMA ALASLMGALL QAALSVFGMV
   421  GGPLMGLFAL GILVPFANSI GALVGLMAGF AISLWVGIGA QIYPPLPERT LPLHLDIQGC
   481  NSTYNETNLM TTTEMPFTTS VFQIYNVQRT PLMDNWYSLS YLYFSTVGTL VTLLVGILVS
   541  LSTGGRKQNL DPRYILTKED FLSNFDIFKK KKHVLSYKSH PVEDGGTDNP AFNHIELNSD
   601  QSGKSNGTRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC5A8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
13
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
19 nTPM

Expression across tissuesHPA

Tissue

  • cervix: 19 nTPM
  • thyroid gland: 15 nTPM
  • kidney: 5.2 nTPM
  • adrenal gland: 2.3 nTPM
  • salivary gland: 0.9 nTPM
  • lung: 0.8 nTPM

Single-cell type

  • proximal tubule cells: 60 nCPM
  • brain inhibitory neurons: 23 nCPM
  • renal connecting tubule cells: 23 nCPM
  • brain excitatory neurons: 17 nCPM
  • other brain neurons: 11 nCPM
  • lacrimal acinar cells: 11 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 3.3 nTPM
  • cerebral cortex: 3.1 nTPM
  • medulla oblongata: 2.2 nTPM
  • white matter: 2.2 nTPM
  • thalamus: 1.7 nTPM
  • basal ganglia: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.2
gnomAD pLI
0
gnomAD missense Z
0.28
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC5A8 as an antibody target. Whether an autoantibody or antibody against SLC5A8 could matter depends on whether native SLC5A8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC5A8 is annotated at the cell surface, where native SLC5A8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC5A8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC5A8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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