Seroatlas · Human Serome Atlas

SLC5A4

Probable glucose sensor protein SLC5A4

Also known as: DJ90G24.4, SAAT1, SC5A4_HUMAN, SGLT3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NY91
Gene
SLC5A4
Ensembl
ENSG00000100191
Chromosome
22
Canonical length
659 aa
Protein class
Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable low-affinity D-glucose:sodium symporter activity. Predicted to be involved in D-glucose transmembrane transport and sodium ion transport. Predicted to act upstream of or within proton transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

659 residues, UniProt reviewed canonical sequence.

>Q9NY91|SLC5A4
     1  MASTVSPSTI AETPEPPPLS DHIRNAADIS VIVIYFLVVM AVGLWAMLKT NRGTIGGFFL
    61  AGRDMAWWPM GASLFASNIG SNHYVGLAGT GAASGVATVT FEWTSSVMLL ILGWIFVPIY
   121  IKSGVMTMPE YLKKRFGGER LQVYLSILSL FICVVLLISA DIFAGAIFIK LALGLDLYLA
   181  IFILLAMTAV YTTTGGLASV IYTDTLQTII MLIGSFILMG FAFNEVGGYE SFTEKYVNAT
   241  PSVVEGDNLT ISASCYTPRA DSFHIFRDAV TGDIPWPGII FGMPITALWY WCTNQVIVQR
   301  CLCGKDMSHV KAACIMCAYL KLLPMFLMVM PGMISRILYT DMVACVVPSE CVKHCGVDVG
   361  CTNYAYPTMV LELMPQGLRG LMLSVMLASL MSSLTSIFNS ASTLFTIDLY TKMRKQASEK
   421  ELLIAGRIFV LLLTVVSIVW VPLVQVSQNG QLIHYTESIS SYLGPPIAAV FVLAIFCKRV
   481  NEQGAFWGLM VGLAMGLIRM ITEFAYGTGS CLAPSNCPKI ICGVHYLYFS IVLFFGSMLV
   541  TLGISLLTKP IPDVHLYRLC WVLRNSTEER IDIDAEEKSQ EETDDGVEED YPEKSRGCLK
   601  KAYDLFCGLQ KGPKLTKEEE EALSKKLTDT SERPSWRTIV NINAILLLAV VVFIHGYYA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC5A4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
11
Mean surface accessibility (rSASA)
0.22
Highest tissue expression
19 nTPM

Expression across tissuesHPA

Tissue

  • small intestine: 19 nTPM
  • duodenum: 17 nTPM
  • lung: 1.4 nTPM
  • smooth muscle: 1.3 nTPM
  • thyroid gland: 1.2 nTPM
  • cervix: 1 nTPM

Single-cell type

  • vascular endothelial cells: 16 nCPM
  • lymphatic endothelial cells: 12 nCPM
  • erythrocyte progenitors: 11 nCPM
  • prostatic glandular cells: 10 nCPM
  • retinal ganglion cells: 7.7 nCPM
  • enterocytes: 7.6 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 12 nTPM
  • pons: 11 nTPM
  • medulla oblongata: 7.6 nTPM
  • white matter: 7.5 nTPM
  • hippocampal formation: 6.8 nTPM
  • hypothalamus: 6.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC5A4.

Disease | ImmuneIEDB

Conditions an epitope on SLC5A4 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.13
gnomAD pLI
0
gnomAD missense Z
0.84
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC5A4 as an antibody target. Whether an autoantibody or antibody against SLC5A4 could matter depends on whether native SLC5A4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC5A4 is annotated at the cell surface, where native SLC5A4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC5A4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC5A4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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