Seroatlas · Human Serome Atlas

SLC5A2

Sodium/glucose cotransporter 2

Also known as: SC5A2_HUMAN, SGLT2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P31639
Gene: SLC5A2
Ensembl: ENSG00000140675
Chromosome: 16
Canonical length: 672 aa
Protein class: Disease related genes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. Two transcript variants, one protein-coding and one not, have been found for this gene. [provided by RefSeq, Feb 2015]

Canonical amino-acid sequenceUniProt

672 residues, UniProt reviewed canonical sequence.

>P31639|SLC5A2
     1  MEEHTEAGSA PEMGAQKALI DNPADILVIA AYFLLVIGVG LWSMCRTNRG TVGGYFLAGR
    61  SMVWWPVGAS LFASNIGSGH FVGLAGTGAA SGLAVAGFEW NALFVVLLLG WLFAPVYLTA
   121  GVITMPQYLR KRFGGRRIRL YLSVLSLFLY IFTKISVDMF SGAVFIQQAL GWNIYASVIA
   181  LLGITMIYTV TGGLAALMYT DTVQTFVILG GACILMGYAF HEVGGYSGLF DKYLGAATSL
   241  TVSEDPAVGN ISSFCYRPRP DSYHLLRHPV TGDLPWPALL LGLTIVSGWY WCSDQVIVQR
   301  CLAGKSLTHI KAGCILCGYL KLTPMFLMVM PGMISRILYP DEVACVVPEV CRRVCGTEVG
   361  CSNIAYPRLV VKLMPNGLRG LMLAVMLAAL MSSLASIFNS SSTLFTMDIY TRLRPRAGDR
   421  ELLLVGRLWV VFIVVVSVAW LPVVQAAQGG QLFDYIQAVS SYLAPPVSAV FVLALFVPRV
   481  NEQGAFWGLI GGLLMGLARL IPEFSFGSGS CVQPSACPAF LCGVHYLYFA IVLFFCSGLL
   541  TLTVSLCTAP IPRKHLHRLV FSLRHSKEER EDLDADEQQG SSLPVQNGCP ESAMEMNEPQ
   601  APAPSLFRQC LLWFCGMSRG GVGSPPPLTQ EEAAAAARRL EDISEDPSWA RVVNLNALLM
   661  MAVAVFLWGF YA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC5A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 13
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 52 nTPM

Expression across tissuesHPA

Tissue

kidney: 52 nTPM
testis: 2.8 nTPM
small intestine: 0.6 nTPM
duodenum: 0.4 nTPM
adipose tissue: 0.1 nTPM
colon: 0.1 nTPM

Single-cell type

late spermatids: 263 nCPM
proximal tubule cells: 140 nCPM
late primary spermatocytes: 98 nCPM
early spermatids: 53 nCPM
cardiomyocytes: 33 nCPM
epicardial cells: 32 nCPM

Immune cell

MAIT T-cell: 0.2 nTPM
memory CD4 T-cell: 0.2 nTPM
NK-cell: 0.2 nTPM
T-reg: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

cerebellum: 2.5 nTPM
cerebral cortex: 0.8 nTPM
pons: 0.7 nTPM
hippocampal formation: 0.6 nTPM
hypothalamus: 0.6 nTPM
midbrain: 0.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC5A2.

Disease | AllUniProt

Conditions SLC5A2 is implicated in, by any mechanism.

Renal glucosuria (GLYS) MIM:233100

Disease | GeneticClinVar

48 pathogenic / likely-pathogenic of 379 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Familial renal glucosuria
SLC5A2-related disorder
Gastric cancer
Renal tubulopathies

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
gnomAD missense Z: -1.16
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC5A2 as an antibody target. Whether an autoantibody or antibody against SLC5A2 could matter depends on whether native SLC5A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC5A2 is annotated at the cell surface, where native SLC5A2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC5A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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