Seroatlas · Human Serome Atlas

SLC5A10

Sodium/mannose cotransporter SLC5A10

Also known as: SC5AA_HUMAN, SGLT5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0PJK1
Gene
SLC5A10
Ensembl
ENSG00000154025
Chromosome
17
Canonical length
596 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene is a member of the sodium/glucose transporter family. Members of this family are sodium-dependent transporters and can be divided into two subfamilies based on sequence homology, one that co-transports sugars and the second that transports molecules such as ascorbate, choline, iodide, lipoate, monocaroboxylates, and pantothenate. The protein encoded by this gene has the highest affinity for mannose and has been reported to be most highly expressed in the kidney. This protein may function as a kidney-specific, sodium-dependent mannose and fructose co-transporter. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

596 residues, UniProt reviewed canonical sequence.

>A0PJK1|SLC5A10
     1  MAANSTSDLH TPGTQLSVAD IIVITVYFAL NVAVGIWSSC RASRNTVNGY FLAGRDMTWW
    61  PIGASLFASS EGSGLFIGLA GSGAAGGLAV AGFEWNATYV LLALAWVFVP IYISSEIVTL
   121  PEYIQKRYGG QRIRMYLSVL SLLLSVFTKI SLDLYAGALF VHICLGWNFY LSTILTLGIT
   181  ALYTIAGGLA AVIYTDALQT LIMVVGAVIL TIKAFDQIGG YGQLEAAYAQ AIPSRTIANT
   241  TCHLPRTDAM HMFRDPHTGD LPWTGMTFGL TIMATWYWCT DQVIVQRSLS ARDLNHAKAG
   301  SILASYLKML PMGLIIMPGM ISRALFPDDV GCVVPSECLR ACGAEVGCSN IAYPKLVMEL
   361  MPIGLRGLMI AVMLAALMSS LTSIFNSSST LFTMDIWRRL RPRSGERELL LVGRLVIVAL
   421  IGVSVAWIPV LQDSNSGQLF IYMQSVTSSL APPVTAVFVL GVFWRRANEQ GAFWGLIAGL
   481  VVGATRLVLE FLNPAPPCGE PDTRPAVLGS IHYLHFAVAL FALSGAVVVA GSLLTPPPQS
   541  VQIENLTWWT LAQDVPLGTK AGDGQTPQKH AFWARVCGFN AILLMCVNIF FYAYFA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC5A10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
14
Mean surface accessibility (rSASA)
0.22
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 39 nTPM
  • spleen: 3 nTPM
  • bone marrow: 2.2 nTPM
  • small intestine: 1.1 nTPM
  • heart muscle: 0.8 nTPM
  • lymph node: 0.8 nTPM

Single-cell type

  • epicardial cells: 214 nCPM
  • proximal tubule cells: 172 nCPM
  • late spermatids: 85 nCPM
  • esophageal suprabasal cells: 44 nCPM
  • suprabasal keratinocytes: 40 nCPM
  • basal keratinocytes: 40 nCPM

Immune cell

  • non-classical monocyte: 4.9 nTPM
  • intermediate monocyte: 1.8 nTPM
  • myeloid DC: 0.6 nTPM
  • total PBMC: 0.3 nTPM
  • naive CD4 T-cell: 0.1 nTPM
  • basophil: 0 nTPM

Brain region

  • thalamus: 0.6 nTPM
  • amygdala: 0.5 nTPM
  • medulla oblongata: 0.5 nTPM
  • pons: 0.5 nTPM
  • basal ganglia: 0.4 nTPM
  • cerebral cortex: 0.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC5A10.

Disease | ImmuneIEDB

Conditions an epitope on SLC5A10 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.04
gnomAD pLI
0
gnomAD missense Z
0.82
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC5A10 as an antibody target. Whether an autoantibody or antibody against SLC5A10 could matter depends on whether native SLC5A10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC5A10 is annotated at the cell surface, where native SLC5A10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC5A10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC5A10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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