Seroatlas · Human Serome Atlas

SLC52A1

Solute carrier family 52, riboflavin transporter, member 1

Also known as: FLJ10060, GPCR42, GPR172B, hRFT1, PAR2, RFVT1, S52A1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NWF4
Gene
SLC52A1
Ensembl
ENSG00000132517
Chromosome
17
Canonical length
448 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

Biological redox reactions require electron donors and acceptor. Vitamin B2 is the source for the flavin in flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) which are common redox reagents. This gene encodes a member of the riboflavin (vitamin B2) transporter family. Haploinsufficiency of this protein can cause maternal riboflavin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]

Canonical amino-acid sequenceUniProt

448 residues, UniProt reviewed canonical sequence.

>Q9NWF4|SLC52A1
     1  MAAPTLGRLV LTHLLVALFG MGSWAAVNGI WVELPVVVKD LPEGWSLPSY LSVVVALGNL
    61  GLLVVTLWRQ LAPGKGEQVP IQVVQVLSVV GTALLAPLWH HVAPVAGQLH SVAFLTLALV
   121  LAMACCTSNV TFLPFLSHLP PPFLRSFFLG QGLSALLPCV LALVQGVGRL ECPPAPTNGT
   181  SGPPLDFPER FPASTFFWAL TALLVTSAAA FRGLLLLLPS LPSVTTGGSG PELQLGSPGA
   241  EEEEKEEEEA LPLQEPPSQA AGTIPGPDPE AHQLFSAHGA FLLGLMAFTS AVTNGVLPSV
   301  QSFSCLPYGR LAYHLAVVLG SAANPLACFL AMGVLCRSLA GLVGLSLLGM LFGAYLMALA
   361  ILSPCPPLVG TTAGVVLVVL SWVLCLCVFS YVKVAASSLL HGGGRPALLA AGVAIQVGSL
   421  LGAGAMFPPT SIYHVFQSRK DCVDPCGP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC52A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
11
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 34 nTPM
  • small intestine: 22 nTPM
  • placenta: 17 nTPM
  • skin: 10 nTPM
  • cervix: 1.2 nTPM
  • esophagus: 1 nTPM

Single-cell type

  • syncytiotrophoblasts: 1,054 nCPM
  • cytotrophoblasts: 225 nCPM
  • migrating cytotrophoblasts: 120 nCPM
  • enterocytes: 95 nCPM
  • goblet cells: 18 nCPM
  • early primary spermatocytes: 17 nCPM

Immune cell

  • neutrophil: 0.7 nTPM
  • basophil: 0.6 nTPM
  • memory CD8 T-cell: 0.2 nTPM
  • naive B-cell: 0.2 nTPM
  • naive CD4 T-cell: 0.2 nTPM
  • NK-cell: 0.2 nTPM

Brain region

  • cerebellum: 3.3 nTPM
  • white matter: 3 nTPM
  • cerebral cortex: 2.9 nTPM
  • pons: 2.6 nTPM
  • amygdala: 2.5 nTPM
  • hippocampal formation: 2.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC52A1.

Disease | AllUniProt

Conditions SLC52A1 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.51
gnomAD pLI
0
gnomAD missense Z
0.05
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC52A1 as an antibody target. Whether an autoantibody or antibody against SLC52A1 could matter depends on whether native SLC52A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC52A1 is annotated at the cell surface, where native SLC52A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC52A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC52A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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