Seroatlas · Human Serome Atlas

SLC4A9

Anion exchange protein 4

Also known as: AE4, B3A4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96Q91
Gene: SLC4A9
Ensembl: ENSG00000113073
Chromosome: 5
Canonical length: 983 aa
Protein class: Metabolic proteins, Plasma proteins, Predicted membrane proteins, Transporters
Subcellular location: Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a membrane protein involved in anion exchange. Expression of this gene is mostly limited to the kidney. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Canonical amino-acid sequenceUniProt

983 residues, UniProt reviewed canonical sequence.

>Q96Q91|SLC4A9
     1  MEMKLPGQEG FEASSAPRNI PSGELDSNPD PGTGPSPDGP SDTESKELGV PKDPLLFIQL
    61  NELLGWPQAL EWRETGSSSA SLLLDMGEMP SITLSTHLHH RWVLFEEKLE VAAGRWSAPH
   121  VPTLALPSLQ KLRSLLAEGL VLLDCPAQSL LELVEQVTRV ESLSPELRGQ LQALLLQRPQ
   181  HYNQTTGTRP CWGSTHPRKA SDNEEAPLRE QCQNPLRQKL PPGAEAGTVL AGELGFLAQP
   241  LGAFVRLRNP VVLGSLTEVS LPSRFFCLLL GPCMLGKGYH EMGRAAAVLL SDPQFQWSVR
   301  RASNLHDLLA ALDAFLEEVT VLPPGRWDPT ARIPPPKCLP SQHKRLPSQQ REIRGPAVPR
   361  LTSAEDRHRH GPHAHSPELQ RTGRLFGGLI QDVRRKVPWY PSDFLDALHL QCFSAVLYIY
   421  LATVTNAITF GGLLGDATDG AQGVLESFLG TAVAGAAFCL MAGQPLTILS STGPVLVFER
   481  LLFSFSRDYS LDYLPFRLWV GIWVATFCLV LVATEASVLV RYFTRFTEEG FCALISLIFI
   541  YDAVGKMLNL THTYPIQKPG SSAYGCLCQY PGPGGNESQW IRTRPKDRDD IVSMDLGLIN
   601  ASLLPPPECT RQGGHPRGPG CHTVPDIAFF SLLLFLTSFF FAMALKCVKT SRFFPSVVRK
   661  GLSDFSSVLA ILLGCGLDAF LGLATPKLMV PREFKPTLPG RGWLVSPFGA NPWWWSVAAA
   721  LPALLLSILI FMDQQITAVI LNRMEYRLQK GAGFHLDLFC VAVLMLLTSA LGLPWYVSAT
   781  VISLAHMDSL RRESRACAPG ERPNFLGIRE QRLTGLVVFI LTGASIFLAP VLKFIPMPVL
   841  YGIFLYMGVA ALSSIQFTNR VKLLLMPAKH QPDLLLLRHV PLTRVHLFTA IQLACLGLLW
   901  IIKSTPAAII FPLMLLGLVG VRKALERVFS PQELLWLDEL MPEEERSIPE KGLEPEHSFS
   961  GSDSEDSELM YQPKAPEINI SVN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC4A9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 11
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

kidney: 37 nTPM
spinal cord: 0.7 nTPM
hippocampal formation: 0.4 nTPM
midbrain: 0.4 nTPM
testis: 0.4 nTPM
seminal vesicle: 0.3 nTPM

Single-cell type

renal collecting duct intercalated cells: 744 nCPM
epididymal clear cells: 16 nCPM
distal convoluted tubule cells: 16 nCPM
renal connecting tubule cells: 10 nCPM
proximal tubule cells: 8.9 nCPM
retinal ganglion cells: 7.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 3.8 nTPM
pons: 3.1 nTPM
medulla oblongata: 2.9 nTPM
cerebral cortex: 2.7 nTPM
basal ganglia: 2.3 nTPM
thalamus: 2.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
gnomAD missense Z: 1.06
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC4A9 as an antibody target. Whether an autoantibody or antibody against SLC4A9 could matter depends on whether native SLC4A9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC4A9 is annotated at the cell surface, where native SLC4A9 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC4A9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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