Seroatlas · Human Serome Atlas

SLC4A8

Electroneutral sodium bicarbonate exchanger 1

Also known as: NBC3, S4A8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q2Y0W8
Gene
SLC4A8
Ensembl
ENSG00000050438
Chromosome
12
Canonical length
1093 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a membrane protein that functions to transport sodium and bicarbonate ions across the cell membrane. The encoded protein is important for pH regulation in neurons. The activity of this protein can be inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Canonical amino-acid sequenceUniProt

1093 residues, UniProt reviewed canonical sequence.

>Q2Y0W8|SLC4A8
     1  MPAAGSNEPD GVLSYQRPDE EAVVDQGGTS TILNIHYEKE ELEGHRTLYV GVRMPLGRQS
    61  HRHHRTHGQK HRRRGRGKGA SQGEEGLEAL AHDTPSQRVQ FILGTEEDEE HVPHELFTEL
   121  DEICMKEGED AEWKETARWL KFEEDVEDGG ERWSKPYVAT LSLHSLFELR SCLINGTVLL
   181  DMHANSIEEI SDLILDQQEL SSDLNDSMRV KVREALLKKH HHQNEKKRNN LIPIVRSFAE
   241  VGKKQSDPHL MDKHGQTVSP QSVPTTNLEV KNGVNCEHSP VDLSKVDLHF MKKIPTGAEA
   301  SNVLVGEVDI LDRPIVAFVR LSPAVLLSGL TEVPIPTRFL FILLGPVGKG QQYHEIGRSM
   361  ATIMTDEIFH DVAYKAKERD DLLAGIDEFL DQVTVLPPGE WDPSIRIEPP KNVPSQEKRK
   421  MPGVPNGNVC HIEQEPHGGH SGPELQRTGR LFGGLVLDIK RKAPWYWSDY RDALSLQCLA
   481  SFLFLYCACM SPVITFGGLL GEATEGRISA IESLFGASMT GIAYSLFAGQ ALTILGSTGP
   541  VLVFEKILFK FCKDYALSYL SLRACIGLWT AFLCIVLVAT DASSLVCYIT RFTEEAFASL
   601  ICIIFIYEAI EKLIHLAETY PIHMHSQLDH LSLYYCRCTL PENPNNHTLQ YWKDHNIVTA
   661  EVHWANLTVS ECQEMHGEFM GSACGHHGPY TPDVLFWSCI LFFTTFILSS TLKTFKTSRY
   721  FPTRVRSMVS DFAVFLTIFT MVIIDFLIGV PSPKLQVPSV FKPTRDDRGW IINPIGPNPW
   781  WTVIAAIIPA LLCTILIFMD QQITAVIINR KEHKLKKGCG YHLDLLMVAI MLGVCSIMGL
   841  PWFVAATVLS ITHVNSLKLE SECSAPGEQP KFLGIREQRV TGLMIFVLMG CSVFMTAILK
   901  FIPMPVLYGV FLYMGVSSLQ GIQFFDRLKL FGMPAKHQPD FIYLRHVPLR KVHLFTLIQL
   961  TCLVLLWVIK ASPAAIVFPM MVLALVFVRK VMDLCFSKRE LSWLDDLMPE SKKKKLDDAK
  1021  KKAKEEEEAE KMLEIGGDKF PLESRKLLSS PGKNISCRCD PSEINISDEM PKTTVWKALS
  1081  MNSGNAKEKS LFN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC4A8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
11
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 17 nTPM
  • cerebellum: 12 nTPM
  • cerebral cortex: 12 nTPM
  • testis: 11 nTPM
  • retina: 10 nTPM
  • hippocampal formation: 9.2 nTPM

Single-cell type

  • thyrotrophs: 400 nCPM
  • somatotrophs: 396 nCPM
  • lactotrophs: 360 nCPM
  • oligodendrocytes: 240 nCPM
  • retinal horizontal cells: 222 nCPM
  • cone photoreceptor cells: 219 nCPM

Immune cell

  • eosinophil: 0.9 nTPM
  • non-classical monocyte: 0.8 nTPM
  • myeloid DC: 0.7 nTPM
  • classical monocyte: 0.5 nTPM
  • NK-cell: 0.5 nTPM
  • basophil: 0.4 nTPM

Brain region

  • pons: 68 nTPM
  • cerebral cortex: 56 nTPM
  • medulla oblongata: 46 nTPM
  • white matter: 41 nTPM
  • hypothalamus: 40 nTPM
  • cerebellum: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.27
gnomAD pLI
1
gnomAD missense Z
4.06
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC4A8 as an antibody target. Whether an autoantibody or antibody against SLC4A8 could matter depends on whether native SLC4A8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC4A8 is annotated at the cell surface, where native SLC4A8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC4A8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC4A8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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