Seroatlas · Human Serome Atlas

SLC4A3

Anion exchange protein 3

Also known as: AE3, B3A3_HUMAN, SLC2C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P48751
Gene
SLC4A3
Ensembl
ENSG00000114923
Chromosome
2
Canonical length
1232 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is a plasma membrane anion exchange protein. The encoded protein has been found in brain, heart, kidney, small intestine, and lung. [provided by RefSeq, May 2016]

Canonical amino-acid sequenceUniProt

1232 residues, UniProt reviewed canonical sequence.

>P48751|SLC4A3
     1  MANGVIPPPG GASPLPQVRV PLEEPPLSPD VEEEDDDLGK TLAVSRFGDL ISKPPAWDPE
    61  KPSRSYSERD FEFHRHTSHH THHPLSARLP PPHKLRRLPP TSARHTRRKR KKEKTSAPPS
   121  EGTPPIQEEG GAGVDEEEEE EEEEEGESEA EPVEPPHSGT PQKAKFSIGS DEDDSPGLPG
   181  RAAVTKPLPS VGPHTDKSPQ HSSSSPSPRA RASRLAGEKS RPWSPSASYD LRERLCPGSA
   241  LGNPGGPEQQ VPTDEAEAQM LGSADLDDMK SHRLEDNPGV RRHLVKKPSR TQGGRGSPSG
   301  LAPILRRKKK KKKLDRRPHE VFVELNELML DRSQEPHWRE TARWIKFEED VEEETERWGK
   361  PHVASLSFRS LLELRRTIAH GAALLDLEQT TLPGIAHLVV ETMIVSDQIR PEDRASVLRT
   421  LLLKHSHPND DKDSGFFPRN PSSSSMNSVL GNHHPTPSHG PDGAVPTMAD DLGEPAPLWP
   481  HDPDAKEKPL HMPGGDGHRG KSLKLLEKIP EDAEATVVLV GCVPFLEQPA AAFVRLNEAV
   541  LLESVLEVPV PVRFLFVMLG PSHTSTDYHE LGRSIATLMS DKLFHEAAYQ ADDRQDLLSA
   601  ISEFLDGSIV IPPSEVEGRD LLRSVAAFQR ELLRKRRERE QTKVEMTTRG GYTAPGKELS
   661  LELGGSEATP EDDPLLRTGS VFGGLVRDVR RRYPHYPSDL RDALHSQCVA AVLFIYFAAL
   721  SPAITFGGLL GEKTEGLMGV SELIVSTAVL GVLFSLLGAQ PLLVVGFSGP LLVFEEAFFK
   781  FCRAQDLEYL TGRVWVGLWL VVFVLALVAA EGSFLVRYIS PFTQEIFAFL ISLIFIYETF
   841  YKLYKVFTEH PLLPFYPPEG ALEGSLDAGL EPNGSALPPT EGPPSPRNQP NTALLSLILM
   901  LGTFFIAFFL RKFRNSRFLG GKARRIIGDF GIPISILVMV LVDYSITDTY TQKLTVPTGL
   961  SVTSPDKRSW FIPPLGSARP FPPWMMVAAA VPALLVLILI FMETQITALI VSQKARRLLK
  1021  GSGFHLDLLL IGSLGGLCGL FGLPWLTAAT VRSVTHVNAL TVMRTAIAPG DKPQIQEVRE
  1081  QRVTGVLIAS LVGLSIVMGA VLRRIPLAVL FGIFLYMGVT SLSGIQLSQR LLLILMPAKH
  1141  HPEQPYVTKV KTWRMHLFTC IQLGCIALLW VVKSTAASLA FPFLLLLTVP LRHCLLPRLF
  1201  QDRELQALDS EDAEPNFDED GQDEYNELHM PV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC4A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
10
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
266 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 266 nTPM
  • ovary: 123 nTPM
  • basal ganglia: 68 nTPM
  • pituitary gland: 40 nTPM
  • cerebral cortex: 38 nTPM
  • amygdala: 37 nTPM

Single-cell type

  • retinal horizontal cells: 351 nCPM
  • cardiomyocytes: 125 nCPM
  • brain inhibitory neurons: 41 nCPM
  • late spermatids: 39 nCPM
  • other brain neurons: 33 nCPM
  • peritubular myoid cells: 30 nCPM

Immune cell

  • plasmacytoid DC: 5.8 nTPM
  • myeloid DC: 1.4 nTPM
  • intermediate monocyte: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • pons: 102 nTPM
  • basal ganglia: 86 nTPM
  • amygdala: 85 nTPM
  • hypothalamus: 83 nTPM
  • thalamus: 79 nTPM
  • medulla oblongata: 78 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC4A3.

Disease | AllUniProt

Conditions SLC4A3 is implicated in, by any mechanism.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 310 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Short QT syndrome 7

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.53
gnomAD pLI
0
gnomAD missense Z
2.74
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC4A3 as an antibody target. Whether an autoantibody or antibody against SLC4A3 could matter depends on whether native SLC4A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC4A3 is annotated at the cell surface, where native SLC4A3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC4A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC4A3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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