Seroatlas · Human Serome Atlas

SLC4A10

Sodium-driven chloride bicarbonate exchanger

Also known as: NBCn2, NCBE, S4A10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6U841
Gene
SLC4A10
Ensembl
ENSG00000144290
Chromosome
2
Canonical length
1118 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

1118 residues, UniProt reviewed canonical sequence.

>Q6U841|SLC4A10
     1  MEIKDQGAQM EPLLPTRNDE EAVVDRGGTR SILKTHFEKE DLEGHRTLFI GVHVPLGGRK
    61  SHRRHRHRGH KHRKRDRERD SGLEDGRESP SFDTPSQRVQ FILGTEDDDE EHIPHDLFTE
   121  LDEICWREGE DAEWRETARW LKFEEDVEDG GERWSKPYVA TLSLHSLFEL RSCILNGTVL
   181  LDMHANTLEE IADMVLDQQV SSGQLNEDVR HRVHEALMKQ HHHQNQKKLT NRIPIVRSFA
   241  DIGKKQSEPN SMDKNAGQVV SPQSAPACVE NKNDVSRENS TVDFSKGLGG QQKGHTSPCG
   301  MKQRHEKGPP HQQEREVDLH FMKKIPPGAE ASNILVGELE FLDRTVVAFV RLSPAVLLQG
   361  LAEVPIPTRF LFILLGPLGK GQQYHEIGRS IATLMTDEVF HDVAYKAKDR NDLVSGIDEF
   421  LDQVTVLPPG EWDPSIRIEP PKNVPSQEKR KIPAVPNGTA AHGEAEPHGG HSGPELQRTG
   481  RIFGGLILDI KRKAPYFWSD FRDAFSLQCL ASFLFLYCAC MSPVITFGGL LGEATEGRIS
   541  AIESLFGASM TGIAYSLFGG QPLTILGSTG PVLVFEKILF KFCKEYGLSY LSLRASIGLW
   601  TATLCIILVA TDASSLVCYI TRFTEEAFAS LICIIFIYEA LEKLFELSEA YPINMHNDLE
   661  LLTQYSCNCV EPHNPSNGTL KEWRESNISA SDIIWENLTV SECKSLHGEY VGRACGHDHP
   721  YVPDVLFWSV ILFFSTVTLS ATLKQFKTSR YFPTKVRSIV SDFAVFLTIL CMVLIDYAIG
   781  IPSPKLQVPS VFKPTRDDRG WFVTPLGPNP WWTVIAAIIP ALLCTILIFM DQQITAVIIN
   841  RKEHKLKKGC GYHLDLLMVA VMLGVCSIMG LPWFVAATVL SITHVNSLKL ESECSAPGEQ
   901  PKFLGIREQR VTGLMIFILM GSSVFMTSIL KFIPMPVLYG VFLYMGASSL KGIQFFDRIK
   961  LFWMPAKHQP DFIYLRHVPL RKVHLFTIIQ MSCLGLLWII KVSRAAIVFP MMVLALVFVR
  1021  KLMDLLFTKR ELSWLDDLMP ESKKKKLEDA EKEEEQSMLA MEDEGTVQLP LEGHYRDDPS
  1081  VINISDEMSK TALWRNLLIT ADNSKDKESS FPSKSSPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC4A10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
54 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 54 nTPM
  • cerebral cortex: 33 nTPM
  • retina: 32 nTPM
  • cerebellum: 13 nTPM
  • basal ganglia: 10 nTPM
  • hypothalamus: 9.5 nTPM

Single-cell type

  • choroid plexus epithelial cells: 2,419 nCPM
  • retinal bipolar cells: 726 nCPM
  • brain excitatory neurons: 537 nCPM
  • brain inhibitory neurons: 523 nCPM
  • other brain neurons: 361 nCPM
  • retinal amacrine cells: 353 nCPM

Immune cell

  • MAIT T-cell: 63 nTPM
  • memory CD8 T-cell: 7.8 nTPM
  • gdT-cell: 2.5 nTPM
  • memory CD4 T-cell: 1.2 nTPM
  • NK-cell: 0.9 nTPM
  • total PBMC: 0.5 nTPM

Brain region

  • choroid plexus: 311 nTPM
  • cerebral cortex: 90 nTPM
  • basal ganglia: 59 nTPM
  • hippocampal formation: 54 nTPM
  • white matter: 50 nTPM
  • hypothalamus: 36 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC4A10.

Disease | AllUniProt

Conditions SLC4A10 is implicated in, by any mechanism.

  • Neurodevelopmental disorder with hypotonia and characteristic brain abnormalities (NEDHBA) MIM:620746

Disease | GeneticClinVar

13 pathogenic / likely-pathogenic of 157 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Neurodevelopmental disorder with hypotonia and characteristic brain abnormalities
  • SLC4A10-related neurodevelopmental disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.38
gnomAD pLI
0.13
gnomAD missense Z
3.84
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC4A10 as an antibody target. Whether an autoantibody or antibody against SLC4A10 could matter depends on whether native SLC4A10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC4A10 is annotated at the cell surface, where native SLC4A10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC4A10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC4A10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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