Seroatlas · Human Serome Atlas

SLC48A1

Heme transporter HRG1

Also known as: FLJ20489, hHRG-1, HRG1, HRG1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P1K1
Gene: SLC48A1
Ensembl: ENSG00000211584
Chromosome: 12
Canonical length: 146 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Vesicles

OverviewNCBI Gene

Enables heme binding activity and heme transmembrane transporter activity. Involved in heme transport. Located in endosome membrane; lysosomal membrane; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

146 residues, UniProt reviewed canonical sequence.

>Q6P1K1|SLC48A1
     1  MAPSRLQLGL RAAYSGISSV AGFSIFLVWT VVYRQPGTAA MGGLAGVLAL WVLVTHVMYM
    61  QDYWRTWLKG LRGFFFVGVL FSAVSIAAFC TFLVLAITRH QSLTDPTSYY LSSVWSFISF
   121  KWAFLLSLYA HRYRADFADI SILSDF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC48A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 131 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 131 nTPM
basal ganglia: 95 nTPM
midbrain: 94 nTPM
hippocampal formation: 91 nTPM
amygdala: 77 nTPM
cerebral cortex: 72 nTPM

Single-cell type

oligodendrocytes: 142 nCPM
esophageal apical cells: 105 nCPM
podocytes: 82 nCPM
renal collecting duct principal cells: 58 nCPM
astrocytes: 54 nCPM
epicardial cells: 52 nCPM

Immune cell

neutrophil: 37 nTPM
classical monocyte: 18 nTPM
intermediate monocyte: 14 nTPM
myeloid DC: 13 nTPM
eosinophil: 12 nTPM
memory B-cell: 10 nTPM

Brain region

white matter: 190 nTPM
basal ganglia: 188 nTPM
midbrain: 180 nTPM
medulla oblongata: 179 nTPM
thalamus: 178 nTPM
cerebellum: 159 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0.73
gnomAD missense Z: 0.77
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Heme transporter HRG
Haem-transporter, endosomal/lysosomal, haem-responsive gene

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC48A1 as an antibody target. Whether an autoantibody or antibody against SLC48A1 could matter depends on whether native SLC48A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC48A1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC48A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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