Seroatlas · Human Serome Atlas

SLC47A1

Multidrug and toxin extrusion protein 1

Also known as: FLJ10847, MATE1, S47A1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96FL8
Gene: SLC47A1
Ensembl: ENSG00000142494
Chromosome: 17
Canonical length: 570 aa
Protein class: Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

570 residues, UniProt reviewed canonical sequence.

>Q96FL8|SLC47A1
     1  MEAPEEPAPV RGGPEATLEV RGSRCLRLSA FREELRALLV LAGPAFLVQL MVFLISFISS
    61  VFCGHLGKLE LDAVTLAIAV INVTGVSVGF GLSSACDTLI SQTYGSQNLK HVGVILQRSA
   121  LVLLLCCFPC WALFLNTQHI LLLFRQDPDV SRLTQTYVTI FIPALPATFL YMLQVKYLLN
   181  QGIVLPQIVT GVAANLVNAL ANYLFLHQLH LGVIGSALAN LISQYTLALL LFLYILGKKL
   241  HQATWGGWSL ECLQDWASFL RLAIPSMLML CMEWWAYEVG SFLSGILGMV ELGAQSIVYE
   301  LAIIVYMVPA GFSVAASVRV GNALGAGDME QARKSSTVSL LITVLFAVAF SVLLLSCKDH
   361  VGYIFTTDRD IINLVAQVVP IYAVSHLFEA LACTSGGVLR GSGNQKVGAI VNTIGYYVVG
   421  LPIGIALMFA TTLGVMGLWS GIIICTVFQA VCFLGFIIQL NWKKACQQAQ VHANLKVNNV
   481  PRSGNSALPQ DPLHPGCPEN LEGILTNDVG KTGEPQSDQQ MRQEEPLPEH PQDGAKLSRK
   541  QLVLRRGLLL LGVFLILLVG ILVRFYVRIQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC47A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 13
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 125 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 125 nTPM
liver: 97 nTPM
kidney: 94 nTPM
tongue: 35 nTPM
skeletal muscle: 32 nTPM
cervix: 28 nTPM

Single-cell type

proximal tubule cells: 454 nCPM
early spermatids: 377 nCPM
late primary spermatocytes: 176 nCPM
epididymal efferent duct absorptive cells: 168 nCPM
myosatellite cells: 156 nCPM
adrenal cortex cells: 140 nCPM

Immune cell

eosinophil: 12 nTPM
plasmacytoid DC: 6.6 nTPM
classical monocyte: 1.4 nTPM
intermediate monocyte: 0.9 nTPM
naive CD8 T-cell: 0.6 nTPM
total PBMC: 0.5 nTPM

Brain region

cerebral cortex: 35 nTPM
hippocampal formation: 34 nTPM
choroid plexus: 21 nTPM
thalamus: 10 nTPM
cerebellum: 8.3 nTPM
white matter: 7.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: -0.19
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC47A1 as an antibody target. Whether an autoantibody or antibody against SLC47A1 could matter depends on whether native SLC47A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC47A1 is annotated at the cell surface, where native SLC47A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC47A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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