Seroatlas · Human Serome Atlas

SLC44A5

Choline transporter-like protein 5

Also known as: CTL5, CTL5_HUMAN, MGC34032

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NCS7
Gene
SLC44A5
Ensembl
ENSG00000137968
Chromosome
1
Canonical length
719 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Cytosol

OverviewNCBI Gene

Enables choline transmembrane transporter activity. Involved in choline transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

719 residues, UniProt reviewed canonical sequence.

>Q8NCS7|SLC44A5
     1  MNDTEKPADT PSEEEDFGDP RTYDPDFKGP VANRSCTDVL CCMIFLLCII GYIVLGLVAW
    61  VHGDPRRAAY PTDSQGHFCG QKGTPNENKT ILFYFNLLRC TSPSVLLNLQ CPTTQICVSK
   121  CPEKFLTYVE MQLLYTKDKS YWEDYRQFCK TTAKPVKSLT QLLLDDDCPT AIFPSKPFLQ
   181  RCFPDFSTKN GTLTIGSKMM FQDGNGGTRS VVELGIAANG INKLLDAKSL GLKVFEDYAR
   241  TWYWILIGLT IAMVLSWIFL ILLRFIAGCL FWVFMIGVIG IIGYGIWHCY QQYTNLQERP
   301  SSVLTIYDIG IQTNISMYFE LQQTWFTFMI ILCIIEVIVI LMLIFLRNRI RVAIILLKEG
   361  SKAIGYVPST LVYPALTFIL LSICICYWVV TAVFLATSGV PVYKVIAPGG HCIHENQTCD
   421  PEIFNTTEIA KACPGALCNF AFYGGKSLYH QYIPTFHVYN LFVFLWLINF VIALGQCALA
   481  GAFATYYWAM KKPDDIPRYP LFTAFGRAIR YHTGSLAFGS LIIALIQMFK IVLEYLDHRL
   541  KRTQNTLSKF LQCCLRCCFW CLENAIKFLN RNAYIMIAIY GRNFCRSAKD AFNLLMRNVL
   601  KVAVTDEVTY FVLFLGKLLV AGSIGVLAFL FFTQRLPVIA QGPASLNYYW VPLLTVIFGS
   661  YLIAHGFFSV YAMCVETIFI CFCEDLERND GSTEKPYFVT PNLHGILIKK QLVPQKQKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC44A5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
10
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
10 nTPM

Expression across tissuesHPA

Tissue

  • skin: 10 nTPM
  • esophagus: 6.2 nTPM
  • breast: 5.2 nTPM
  • testis: 4.2 nTPM
  • placenta: 3.6 nTPM
  • parathyroid gland: 3.5 nTPM

Single-cell type

  • gonadotrophs: 919 nCPM
  • other brain neurons: 368 nCPM
  • oligodendrocyte progenitor cells: 366 nCPM
  • thyrotrophs: 319 nCPM
  • thymic myoid cells: 284 nCPM
  • early spermatids: 279 nCPM

Immune cell

  • memory B-cell: 0.7 nTPM
  • naive B-cell: 0.4 nTPM
  • memory CD8 T-cell: 0.2 nTPM
  • MAIT T-cell: 0.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • naive CD4 T-cell: 0.1 nTPM

Brain region

  • cerebral cortex: 10 nTPM
  • pons: 8.9 nTPM
  • thalamus: 8.1 nTPM
  • spinal cord: 7.7 nTPM
  • hypothalamus: 7.1 nTPM
  • medulla oblongata: 6.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0
gnomAD missense Z
1.18
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC44A5 as an antibody target. Whether an autoantibody or antibody against SLC44A5 could matter depends on whether native SLC44A5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC44A5 is annotated at the cell surface, where native SLC44A5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC44A5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC44A5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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