Seroatlas · Human Serome Atlas

SLC44A2

Choline transporter-like protein 2

Also known as: CTL2, CTL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IWA5
Gene
SLC44A2
Ensembl
ENSG00000129353
Chromosome
19
Canonical length
706 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Vesicles,Cell Junctions

OverviewNCBI Gene

Enables choline transmembrane transporter activity and ethanolamine transmembrane transporter activity. Involved in choline transport; ethanolamine transport; and transmembrane transport. Located in mitochondrial outer membrane and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

706 residues, UniProt reviewed canonical sequence.

>Q8IWA5|SLC44A2
     1  MGDERPHYYG KHGTPQKYDP TFKGPIYNRG CTDIICCVFL LLAIVGYVAV GIIAWTHGDP
    61  RKVIYPTDSR GEFCGQKGTK NENKPYLFYF NIVKCASPLV LLEFQCPTPQ ICVEKCPDRY
   121  LTYLNARSSR DFEYYKQFCV PGFKNNKGVA EVLQDGDCPA VLIPSKPLAR RCFPAIHAYK
   181  GVLMVGNETT YEDGHGSRKN ITDLVEGAKK ANGVLEARQL AMRIFEDYTV SWYWIIIGLV
   241  IAMAMSLLFI ILLRFLAGIM VWVMIIMVIL VLGYGIFHCY MEYSRLRGEA GSDVSLVDLG
   301  FQTDFRVYLH LRQTWLAFMI ILSILEVIII LLLIFLRKRI LIAIALIKEA SRAVGYVMCS
   361  LLYPLVTFFL LCLCIAYWAS TAVFLSTSNE AVYKIFDDSP CPFTAKTCNP ETFPSSNESR
   421  QCPNARCQFA FYGGESGYHR ALLGLQIFNA FMFFWLANFV LALGQVTLAG AFASYYWALR
   481  KPDDLPAFPL FSAFGRALRY HTGSLAFGAL ILAIVQIIRV ILEYLDQRLK AAENKFAKCL
   541  MTCLKCCFWC LEKFIKFLNR NAYIMIAIYG TNFCTSARNA FFLLMRNIIR VAVLDKVTDF
   601  LFLLGKLLIV GSVGILAFFF FTHRIRIVQD TAPPLNYYWV PILTVIVGSY LIAHGFFSVY
   661  GMCVDTLFLC FLEDLERNDG SAERPYFMSS TLKKLLNKTN KKAAES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC44A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
10
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
148 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 148 nTPM
  • skeletal muscle: 137 nTPM
  • blood vessel: 124 nTPM
  • spleen: 109 nTPM
  • stomach: 107 nTPM
  • lung: 93 nTPM

Single-cell type

  • platelets: 378 nCPM
  • neutrophils: 356 nCPM
  • extravillous trophoblasts: 356 nCPM
  • migrating cytotrophoblasts: 270 nCPM
  • early spermatids: 223 nCPM
  • esophageal apical cells: 215 nCPM

Immune cell

  • neutrophil: 485 nTPM
  • non-classical monocyte: 280 nTPM
  • eosinophil: 229 nTPM
  • total PBMC: 147 nTPM
  • basophil: 147 nTPM
  • gdT-cell: 114 nTPM

Brain region

  • medulla oblongata: 180 nTPM
  • white matter: 169 nTPM
  • spinal cord: 147 nTPM
  • basal ganglia: 144 nTPM
  • thalamus: 137 nTPM
  • cerebellum: 133 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.56
gnomAD pLI
0
gnomAD missense Z
0.98
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC44A2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC44A2 as an antibody target. Whether an autoantibody or antibody against SLC44A2 could matter depends on whether native SLC44A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC44A2 is annotated at the cell surface, where native SLC44A2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC44A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC44A2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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