Seroatlas · Human Serome Atlas

SLC44A1

Choline transporter-like protein 1

Also known as: CD92, CDW92, CHTL1, CTL1, CTL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WWI5
Gene
SLC44A1
Ensembl
ENSG00000070214
Chromosome
9
Canonical length
657 aa
Protein class
CD markers, Disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Mitochondria

OverviewNCBI Gene

Enables choline transmembrane transporter activity and ethanolamine transmembrane transporter activity. Involved in choline transport; ethanolamine transport; and transmembrane transport. Located in several cellular components, including cytosol; mitochondrial outer membrane; and nucleoplasm. Implicated in high grade glioma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

657 residues, UniProt reviewed canonical sequence.

>Q8WWI5|SLC44A1
     1  MGCCSSASSA AQSSKREWKP LEDRSCTDIP WLLLFILFCI GMGFICGFSI ATGAAARLVS
    61  GYDSYGNICG QKNTKLEAIP NSGMDHTQRK YVFFLDPCNL DLINRKIKSV ALCVAACPRQ
   121  ELKTLSDVQK FAEINGSALC SYNLKPSEYT TSPKSSVLCP KLPVPASAPI PFFHRCAPVN
   181  ISCYAKFAEA LITFVSDNSV LHRLISGVMT SKEIILGLCL LSLVLSMILM VIIRYISRVL
   241  VWILTILVIL GSLGGTGVLW WLYAKQRRSP KETVTPEQLQ IAEDNLRALL IYAISATVFT
   301  VILFLIMLVM RKRVALTIAL FHVAGKVFIH LPLLVFQPFW TFFALVLFWV YWIMTLLFLG
   361  TTGSPVQNEQ GFVEFKISGP LQYMWWYHVV GLIWISEFIL ACQQMTVAGA VVTYYFTRDK
   421  RNLPFTPILA SVNRLIRYHL GTVAKGSFII TLVKIPRMIL MYIHSQLKGK ENACARCVLK
   481  SCICCLWCLE KCLNYLNQNA YTATAINSTN FCTSAKDAFV ILVENALRVA TINTVGDFML
   541  FLGKVLIVCS TGLAGIMLLN YQQDYTVWVL PLIIVCLFAF LVAHCFLSIY EMVVDVLFLC
   601  FAIDTKYNDG SPGREFYMDK VLMEFVENSR KAMKEAGKGG VADSRELKPM ASGASSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC44A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
9
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
230 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 230 nTPM
  • midbrain: 116 nTPM
  • hippocampal formation: 93 nTPM
  • basal ganglia: 83 nTPM
  • amygdala: 72 nTPM
  • colon: 65 nTPM

Single-cell type

  • oligodendrocytes: 3,391 nCPM
  • megakaryocyte progenitors: 1,005 nCPM
  • mast cells: 526 nCPM
  • cone photoreceptor cells: 501 nCPM
  • renal collecting duct principal cells: 488 nCPM
  • foveolar cells: 452 nCPM

Immune cell

  • NK-cell: 8.5 nTPM
  • classical monocyte: 3.8 nTPM
  • myeloid DC: 2.6 nTPM
  • naive B-cell: 2.4 nTPM
  • basophil: 1.8 nTPM
  • memory B-cell: 1.6 nTPM

Brain region

  • white matter: 520 nTPM
  • medulla oblongata: 364 nTPM
  • basal ganglia: 354 nTPM
  • midbrain: 276 nTPM
  • cerebellum: 276 nTPM
  • spinal cord: 260 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC44A1.

Disease | AllUniProt

Conditions SLC44A1 is implicated in, by any mechanism.

  • Neurodegeneration, childhood-onset, with ataxia, tremor, optic atrophy, and cognitive decline (CONATOC) MIM:618868

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 135 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.27
gnomAD pLI
1
gnomAD missense Z
1.73
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC44A1 as an antibody target. Whether an autoantibody or antibody against SLC44A1 could matter depends on whether native SLC44A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC44A1 is annotated at the cell surface, where native SLC44A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC44A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC44A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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