Seroatlas · Human Serome Atlas

SLC41A3

Solute carrier family 41 member 3

Also known as: FLJ20473, S41A3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96GZ6
Gene: SLC41A3
Ensembl: ENSG00000114544
Chromosome: 3
Canonical length: 507 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Plasma membrane

OverviewNCBI Gene

Enables magnesium:sodium antiporter activity. Involved in mitochondrial magnesium ion transmembrane transport. Located in mitochondrial inner membrane and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

507 residues, UniProt reviewed canonical sequence.

>Q96GZ6|SLC41A3
     1  MDGTETRQRR LDSCGKPGEL GLPHPLSTGG LPVASEDGAL RAPESQSVTP KPLETEPSRE
    61  TTWSIGLQVT VPFMFAGLGL SWAGMLLDYF QHWPVFVEVK DLLTLVPPLV GLKGNLEMTL
   121  ASRLSTAANT GQIDDPQEQH RVISSNLALI QVQATVVGLL AAVAALLLGV VSREEVDVAK
   181  VELLCASSVL TAFLAAFALG VLMVCIVIGA RKLGVNPDNI ATPIAASLGD LITLSILALV
   241  SSFFYRHKDS RYLTPLVCLS FAALTPVWVL IAKQSPPIVK ILKFGWFPII LAMVISSFGG
   301  LILSKTVSKQ QYKGMAIFTP VICGVGGNLV AIQTSRISTY LHMWSAPGVL PLQMKKFWPN
   361  PCSTFCTSEI NSMSARVLLL LVVPGHLIFF YIIYLVEGQS VINSQTFVVL YLLAGLIQVT
   421  ILLYLAEVMV RLTWHQALDP DNHCIPYLTG LGDLLGSSSV GHTAAVPRRC TASPGWGLIQ
   481  PFICTQHLIV SLLSFYFPFC LLAKTSI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC41A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 10
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 64 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 64 nTPM
blood vessel: 59 nTPM
skeletal muscle: 58 nTPM
cerebral cortex: 56 nTPM
choroid plexus: 53 nTPM
epididymis: 52 nTPM

Single-cell type

lymphatic endothelial cells: 57 nCPM
decidual stromal cells: 51 nCPM
peritubular myoid cells: 50 nCPM
extravillous trophoblasts: 48 nCPM
undifferentiated spermatogonia: 45 nCPM
cholangiocytes: 43 nCPM

Immune cell

T-reg: 22 nTPM
NK-cell: 15 nTPM
basophil: 13 nTPM
memory CD8 T-cell: 12 nTPM
gdT-cell: 12 nTPM
memory CD4 T-cell: 11 nTPM

Brain region

pons: 78 nTPM
cerebral cortex: 73 nTPM
cerebellum: 70 nTPM
basal ganglia: 68 nTPM
hypothalamus: 68 nTPM
medulla oblongata: 67 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0
gnomAD missense Z: 0.59
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mitochondrial magnesium ion transmembrane transport

Molecular functions

magnesium:sodium antiporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC41A3 as an antibody target. Whether an autoantibody or antibody against SLC41A3 could matter depends on whether native SLC41A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC41A3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC41A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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